Imaging cellular microtubules with the atomic-force microscope

Brenda L. Dixon Northern, Mary A. Jordan, Leslie Wilson, Joseph A. Zasadzinski

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We have immobilized chemically-fixed cellular microtubules and microtubule protein polymers on glow-discharged glass discs for scanning by atomic force microscopy (AFM). The images obtained by AFM resembled those obtained by conventional transmission electron microscopy of the same material. The AFM images can resolve some of the surface features of microtubules to 10 nm. Improvements in the techniques promise resolution approaching molecular dimensions.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherPubl by Int Soc for Optical Engineering
Number of pages7
ISBN (Print)0819407852
StatePublished - Jan 1 1992
EventScanning Probe Microscopies - Los Angeles, CA, USA
Duration: Jan 20 1992Jan 22 1992


OtherScanning Probe Microscopies
CityLos Angeles, CA, USA


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