Imaging cardiac extracellular matrices: A blueprint for regeneration

Jangwook P. Jung, Jayne M. Squirrell, Gary E. Lyons, Kevin W. Eliceiri, Brenda M. Ogle

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Once damaged, cardiac tissue does not readily repair and is therefore a primary target of regenerative therapies. One regenerative approach is the development of scaffolds that functionally mimic the cardiac extracellular matrix (ECM) to deliver stem cells or cardiac precursor populations to the heart. Technological advances in micro/nanotechnology, stem cell biology, biomaterials and tissue decellularization have propelled this promising approach forward. Surprisingly, technological advances in optical imaging methods have not been fully utilized in the field of cardiac regeneration. Here, we describe and provide examples to demonstrate how advanced imaging techniques could revolutionize how ECM-mimicking cardiac tissues are informed and evaluated.

Original languageEnglish (US)
Pages (from-to)233-240
Number of pages8
JournalTrends in biotechnology
Issue number4
StatePublished - Apr 2012


  • Biomaterials
  • Developing heart
  • Extracellular matrix
  • Multimodality imaging
  • Tissue engineering

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