Imaging cardiac extracellular matrices: A blueprint for regeneration

Philip Jung, Jayne M. Squirrell, Gary E. Lyons, Kevin W. Eliceiri, Brenda M Ogle

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Once damaged, cardiac tissue does not readily repair and is therefore a primary target of regenerative therapies. One regenerative approach is the development of scaffolds that functionally mimic the cardiac extracellular matrix (ECM) to deliver stem cells or cardiac precursor populations to the heart. Technological advances in micro/nanotechnology, stem cell biology, biomaterials and tissue decellularization have propelled this promising approach forward. Surprisingly, technological advances in optical imaging methods have not been fully utilized in the field of cardiac regeneration. Here, we describe and provide examples to demonstrate how advanced imaging techniques could revolutionize how ECM-mimicking cardiac tissues are informed and evaluated.

Original languageEnglish (US)
Pages (from-to)233-240
Number of pages8
JournalTrends in biotechnology
Volume30
Issue number4
DOIs
StatePublished - Jan 1 2012

Fingerprint

Blueprints
Extracellular Matrix
Regeneration
Tissue
Stem cells
Imaging techniques
Stem Cells
Cytology
Nanotechnology
Optical Imaging
Biocompatible Materials
Biomaterials
Scaffolds
Cell Biology
Repair
Population
Therapeutics

Keywords

  • Biomaterials
  • Developing heart
  • Extracellular matrix
  • Multimodality imaging
  • Tissue engineering

Cite this

Imaging cardiac extracellular matrices : A blueprint for regeneration. / Jung, Philip; Squirrell, Jayne M.; Lyons, Gary E.; Eliceiri, Kevin W.; Ogle, Brenda M.

In: Trends in biotechnology, Vol. 30, No. 4, 01.01.2012, p. 233-240.

Research output: Contribution to journalReview article

Jung, Philip ; Squirrell, Jayne M. ; Lyons, Gary E. ; Eliceiri, Kevin W. ; Ogle, Brenda M. / Imaging cardiac extracellular matrices : A blueprint for regeneration. In: Trends in biotechnology. 2012 ; Vol. 30, No. 4. pp. 233-240.
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