Imaging brain function in humans at 7 Tesla

Essa Yacoub, Amir Shmuel, Josef Pfeuffer, Pierre Francois Van De Moortele, Gregor Adriany, Peter Andersen, J. Thomas Vaughan, Hellmut Merkle, Kamil Ugurbil, Xiaoping Hu

Research output: Contribution to journalArticlepeer-review

366 Scopus citations


This article describes experimental studies performed to demonstrate the feasibility of BOLD fMRI using echo-planar imaging (EPI) at 7 T and to characterize the BOLD response in humans at this ultrahigh magnetic field. Visual stimulation studies were performed in normal subjects using high-resolution multishot EPI sequences. Changes in R2* arising from visual stimulation were experimentally determined using fMRI measurements obtained at multiple echo times. The results obtained at 7 T were compared to those at 4 T. Experimental data indicate that fMRI can be reliably performed at 7 T and that at this field strength both the sensitivity and spatial specificity of the BOLD response are increased. This study suggests that ultrahigh field MR systems are advantageous for functional mapping in humans.

Original languageEnglish (US)
Pages (from-to)588-594
Number of pages7
JournalMagnetic resonance in medicine
Issue number4
StatePublished - 2001


  • BOLD
  • Cerebral function
  • Functional imaging
  • MRI
  • Ultrahigh field
  • fMRI


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