Imaging brain function in humans at 7 Tesla

Essa Yacoub, Amir Shmuel, Josef Pfeuffer, Pierre Francois Van De Moortele, Gregor Adriany, Peter Andersen, J. Thomas Vaughan, Hellmut Merkle, Kamil Ugurbil, Xiaoping Hu

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Abstract

This article describes experimental studies performed to demonstrate the feasibility of BOLD fMRI using echo-planar imaging (EPI) at 7 T and to characterize the BOLD response in humans at this ultrahigh magnetic field. Visual stimulation studies were performed in normal subjects using high-resolution multishot EPI sequences. Changes in R2* arising from visual stimulation were experimentally determined using fMRI measurements obtained at multiple echo times. The results obtained at 7 T were compared to those at 4 T. Experimental data indicate that fMRI can be reliably performed at 7 T and that at this field strength both the sensitivity and spatial specificity of the BOLD response are increased. This study suggests that ultrahigh field MR systems are advantageous for functional mapping in humans.

Original languageEnglish (US)
Pages (from-to)588-594
Number of pages7
JournalMagnetic resonance in medicine
Volume45
Issue number4
DOIs
StatePublished - Apr 12 2001

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Keywords

  • BOLD
  • Cerebral function
  • Functional imaging
  • MRI
  • Ultrahigh field
  • fMRI

Cite this

Yacoub, E., Shmuel, A., Pfeuffer, J., Van De Moortele, P. F., Adriany, G., Andersen, P., Thomas Vaughan, J., Merkle, H., Ugurbil, K., & Hu, X. (2001). Imaging brain function in humans at 7 Tesla. Magnetic resonance in medicine, 45(4), 588-594. https://doi.org/10.1002/mrm.1080