Image-guided drug delivery in lung cancer

Timothy S Wiedmann, Tanmoy Sadhukha, Bruce E Hammer, Jayanth Panyam

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Lung cancer continues to be the number one cause of cancer-related deaths in the USA. Early identification of the disease, availability of more effective drugs, and improved delivery of such drugs specifically to cancer cells are needed to decrease lung cancer-associated morbidity and mortality. The concept of image-guided drug delivery (IGDD), which envisions the utilization of imaging techniques for quantitative assessments of tumor-targeted drug delivery and therapeutic response, has the potential to make a significant impact in lung cancer. While the anatomic and physiological features of the lung pose distinct problems for imaging drug delivery, several new techniques are emerging that have the potential to overcome these problems. X-ray is a routinely used technique for diagnosing lung cancer; however, positron emission tomography (PET) and magnetic resonance imaging (MRI) are complementary approaches. PET- and MRI-based techniques (such as functional MRI) offer the possibility of imaging the delivery f specific molecules to cancer tissues in the lung. This paper reviews fundamentals of imaging with an emphasis on MRI and to some extent PET, since it will be argued that these techniques are the most promising for development in IGDD for lung cancer. Finally, key literature contributions will be highlighted, which exemplify the current successes in this area.

Original languageEnglish (US)
Pages (from-to)31-44
Number of pages14
JournalDrug Delivery and Translational Research
Volume2
Issue number1
DOIs
StatePublished - Sep 3 2012

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Lung Neoplasms
Magnetic Resonance Imaging
Pharmaceutical Preparations
Positron-Emission Tomography
Neoplasms
Lung
X-Rays
Morbidity
Mortality
Therapeutics

Keywords

  • Computed tomography
  • Diagnosis
  • Magnetic resonance imaging
  • Positron emission tomography
  • Targeted drug delivery
  • X-ray

Cite this

Image-guided drug delivery in lung cancer. / Wiedmann, Timothy S; Sadhukha, Tanmoy; Hammer, Bruce E; Panyam, Jayanth.

In: Drug Delivery and Translational Research, Vol. 2, No. 1, 03.09.2012, p. 31-44.

Research output: Contribution to journalReview article

Wiedmann, Timothy S ; Sadhukha, Tanmoy ; Hammer, Bruce E ; Panyam, Jayanth. / Image-guided drug delivery in lung cancer. In: Drug Delivery and Translational Research. 2012 ; Vol. 2, No. 1. pp. 31-44.
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