Image-based multiscale structural models of fibrous engineered tissues.

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3 Citations (Scopus)

Abstract

While it is firmly established that the mechanical behavior of most biological tissues, including bioengineered tissues, is governed by an underlying network of protein fibers, it is still not clear how best to obtain and utilize structural information to predict mechanical response. In this paper, methods are presented to (1) quantify the fiber arrangement in a tissue from different imaging tools, (2) incorporate that structure into a multiscale model, and (3) solve the model equations to predict both the microscopic and the macroscopic tissue response. In principle these concepts could be applied to any tissue (incorporating the specific tissue components as needed), but for demonstration purposes, the focus of the current work is on cell-compacted collagen gel, a model engineered tissue.

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Structural Models
Tissue
Fibers
Collagen
Demonstrations
Gels
Proteins
Imaging techniques

Cite this

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title = "Image-based multiscale structural models of fibrous engineered tissues.",
abstract = "While it is firmly established that the mechanical behavior of most biological tissues, including bioengineered tissues, is governed by an underlying network of protein fibers, it is still not clear how best to obtain and utilize structural information to predict mechanical response. In this paper, methods are presented to (1) quantify the fiber arrangement in a tissue from different imaging tools, (2) incorporate that structure into a multiscale model, and (3) solve the model equations to predict both the microscopic and the macroscopic tissue response. In principle these concepts could be applied to any tissue (incorporating the specific tissue components as needed), but for demonstration purposes, the focus of the current work is on cell-compacted collagen gel, a model engineered tissue.",
author = "Sander, {Edward A.} and Tranquillo, {Robert T.} and Barocas, {Victor H.}",
year = "2009",
doi = "10.1109/IEMBS.2009.5334586",
language = "English (US)",
pages = "4270--4272",
journal = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
issn = "1557-170X",
publisher = "Institute of Electrical and Electronics Engineers Inc.",

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T1 - Image-based multiscale structural models of fibrous engineered tissues.

AU - Sander, Edward A.

AU - Tranquillo, Robert T.

AU - Barocas, Victor H.

PY - 2009

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N2 - While it is firmly established that the mechanical behavior of most biological tissues, including bioengineered tissues, is governed by an underlying network of protein fibers, it is still not clear how best to obtain and utilize structural information to predict mechanical response. In this paper, methods are presented to (1) quantify the fiber arrangement in a tissue from different imaging tools, (2) incorporate that structure into a multiscale model, and (3) solve the model equations to predict both the microscopic and the macroscopic tissue response. In principle these concepts could be applied to any tissue (incorporating the specific tissue components as needed), but for demonstration purposes, the focus of the current work is on cell-compacted collagen gel, a model engineered tissue.

AB - While it is firmly established that the mechanical behavior of most biological tissues, including bioengineered tissues, is governed by an underlying network of protein fibers, it is still not clear how best to obtain and utilize structural information to predict mechanical response. In this paper, methods are presented to (1) quantify the fiber arrangement in a tissue from different imaging tools, (2) incorporate that structure into a multiscale model, and (3) solve the model equations to predict both the microscopic and the macroscopic tissue response. In principle these concepts could be applied to any tissue (incorporating the specific tissue components as needed), but for demonstration purposes, the focus of the current work is on cell-compacted collagen gel, a model engineered tissue.

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JO - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

JF - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

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