IL28B genetic variations are associated with high sustained virological response (SVR) of interferon-α plus ribavirin therapy in Taiwanese chronic HCV infection

J. Y. Chen, C. Y. Lin, C. M. Wang, Y. T. Lin, S. N. Kuo, C. F. Shiu, S. W. Chang, Jianming Wu, I. S. Sheen

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Chronic hepatitis C virus (HCV) infection patients exhibit different sustained virological responses (SVRs) following the treatment with pegylated interferon-α (IFN-α) and ribavirin. Genome-wide association studies consistently linked SVR of IFN-α-based therapy to the IL28B single-nucleotide polymorphisms (SNPs) on chromosome 19q.13 in various populations. This study was undertaken to investigate the association of IL28B SNPs with SVR in a cohort of Taiwanese chronic HCV patients. Ten SNPs of IL28B were genotyped in 728 chronic HCV patients and 960 healthy controls. Genotype distributions, allele frequencies and haplotypes were tested for SVR and susceptibility in Taiwanese chronic HCV patients. Non-genotype 1 infection (adjusted P3.3 × 10 12, odds ratio (OR) 0.179; 95% confidence interval (CI): 0.110-0.290) and low HCV viral load (400 000 IU ml-1) (adjusted P3.5 × 10 9, OR 0.299; 95% CI: 0.200-0.446) were two major factors identified for high SVR. Notably, eight IL28B SNPs including previously described disease-associated SNPs (Trend test P0.005) were significantly associated with SVR. Our data indicate that IL28B polymorphisms are the essential contributing factors for high SVR in Taiwanese chronic HCV patients. Combination of virus genotyping and host genetic data may be used to select the optimal treatment regimes in IFN-based therapy.

Original languageEnglish (US)
Pages (from-to)300-309
Number of pages10
JournalGenes and Immunity
Volume12
Issue number4
DOIs
StatePublished - Jun 2011

Bibliographical note

Funding Information:
We thank Shin Chu Blood Donor Center for samples collection. This study was supported by grants from the Chang Gung Memorial Hospital (No. CMRPG 380681 and CMRPG 360113).

Keywords

  • IL28B
  • hepatitis C
  • single-nucleotide polymorphisms
  • sustained virological response

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