IgG Fc receptor polymorphisms in human disease: Implications for intravenous immunoglobulin therapy

Bryce A. Binstadt, Raif S. Geha, Francisco A. Bonilla

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations

Abstract

Polymorphisms of human Fc receptors (FcRs) have been described that are associated with the development or progression of autoimmune diseases. The FcR polymorphisms affect the affinity with which FcRs interact with immunoglobulin molecules. Intravenous immunoglobulin is administered as therapy for many autoimmune diseases and might exert its effects by interacting with FcRs. Thus, FcR polymorphisms might influence the efficacy of intravenous immunoglobulin therapy for patients with certain autoimmune diseases. In this article we review FcR polymorphisms in relation to autoimmune diseases for which intravenous immunoglobulin is used therapeutically.

Original languageEnglish (US)
Pages (from-to)697-703
Number of pages7
JournalJournal of Allergy and Clinical Immunology
Volume111
Issue number4
DOIs
StatePublished - Apr 1 2003
Externally publishedYes

Keywords

  • Autoimmune
  • Fc receptor
  • Guillain-Barré
  • ITP
  • Intravenous immunoglobulin
  • Lupus
  • Multiple sclerosis
  • Polymorphism
  • Vasculitis

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