IGF 1 and IGF 2

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Insulin-like growth factor-1 (IGF-1) and IGF-2 are circulating peptide growth factor hormones important in normal growth and development. Their biological effects are mediated by specific cell surface receptors, the type I IGF receptor (IGF1R) and the insulin receptor. In cancer, preclinical and epidemiological evidence support a role for these growth factors in regulating cancer risk and tumor biology. Thus, neutralization of these growth factors could play a role in cancer prevention and therapy.

Original languageEnglish (US)
Title of host publicationCancer Therapeutic Targets
PublisherSpringer New York
Pages739-743
Number of pages5
Volume2-2
ISBN (Electronic)9781441907172
ISBN (Print)9781441907165
DOIs
StatePublished - Jan 1 2017

Keywords

  • Growth Factor
  • Insulin-like growth factors

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