Insulin-like growth factor-1 (IGF-1) and IGF-2 are circulating peptide growth factor hormones important in normal growth and development. Their biological effects are mediated by specific cell surface receptors, the type I IGF receptor (IGF1R) and the insulin receptor. In cancer, preclinical and epidemiological evidence support a role for these growth factors in regulating cancer risk and tumor biology. Thus, neutralization of these growth factors could play a role in cancer prevention and therapy.
- Growth Factor
- Insulin-like growth factors