IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update

Nancy L. Pedersen, Margaret Gatz, Brian K. Finch, Deborah Finkel, David A. Butler, Anna Dahl Aslan, Carol E. Franz, Jaakko Kaprio, Susan Lapham, Matt McGue, Miriam A. Mosing, Jenae Neiderhiser, Marianne Nygaard, Matthew Panizzon, Carol A. Prescott, Chandra A. Reynolds, Perminder Sachdev, Keith E. Whitfield

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The Interplay of Genes and Environment across Multiple Studies (IGEMS) is a consortium of 18 twin studies from 5 different countries (Sweden, Denmark, Finland, United States, and Australia) established to explore the nature of gene-environment (GE) interplay in functioning across the adult lifespan. Fifteen of the studies are longitudinal, with follow-up as long as 59 years after baseline. The combined data from over 76,000 participants aged 14-103 at intake (including over 10,000 monozygotic and over 17,000 dizygotic twin pairs) support two primary research emphases: (1) investigation of models of GE interplay of early life adversity, and social factors at micro and macro environmental levels and with diverse outcomes, including mortality, physical functioning and psychological functioning; and (2) improved understanding of risk and protective factors for dementia by incorporating unmeasured and measured genetic factors with a wide range of exposures measured in young adulthood, midlife and later life.

Original languageEnglish (US)
Pages (from-to)809-816
Number of pages8
JournalTwin Research and Human Genetics
Volume22
Issue number6
DOIs
StatePublished - Dec 1 2019

Bibliographical note

Funding Information:
Members of the IGEMS Consortium include Karolinska Institutet: Nancy Pedersen, Miriam Mosing, Malin Ericsson; Jnkping University: Anna Dahl Aslan, Ida Karlsson; University of Southern California: Margaret Gatz, Brian Finch, Kyla Thomas, Christopher Beam, Susan Luczak, Carol Prescott, Em Arpawong, Catalina Zavala, Andrew Petkus; University of Southern Denmark: Kaare Christensen, Marianne Nygaard, Mette Wod; University of Minnesota: Matt McGue, Robert Krueger; University of California, Riverside: Chandra Reynolds, Elizabeth Munoz, Shandell Pahlen, Dianna Phillips; Indiana University Southeast: Deborah Finkel; University of California, San Diego: William Kremen, Carol Franz, Matthew Panizzon, Jeremy Elman, Daniel Gustavson; Edinburgh University: Wendy Johnson; The Pennsylvania State University: Jenae Neiderhiser; Boston University: Michael Lyons; Wayne State University: Keith Whitfield; University of Helsinki: Jaakko Kaprio, Elina Sillanp, Eero Vuoksimaa; University of New South Wales: Perminder Sachdev, Vibeke Catts, Marie Kondo, Teresa Lee, Karen Mather, Anbu Thalamuthu, Simone Reppermund; QIMR Berghofer: Nicholas G. Martin; American Institutes for Research: Susan Lapham, Kelly Peters; National Academies of Sciences, Engineering and Medicine: David Butler; Duke University: Brenda Plassman. We thank Patricia St. Clair and Ellen Walters for their work on data management. IGEMS is supported by the National Institutes of Health Grants No. R01 AG037985, R56 AG037985, R01 AG059329, R01 AG060470, RF1 AG058068. SATSA was supported by grants R01 AG04563, R01 AG10175, the John D. and Catherine T. MacArthur Foundation Research Network on Successful Aging, the Swedish Council For Working Life and Social Research (FAS) (97:0147:1B, 2009-0795) and Swedish Research Council (825-2007-7460, 825-2009-6141). OCTO-Twin was supported by grant R01 AG08861. Gender was supported by the MacArthur Foundation Research Network on Successful Aging, The Axel and Margaret Ax:son Johnsons Foundation, The Swedish Council for Social Research and the Swedish Foundation for Health Care Sciences and Allergy Research. TOSS was supported by grant R01 MH54610 from the National Institutes of Health. The Danish Twin Registry is supported by grants from The National Program for Research Infrastructure 2007 from the Danish Agency for Science and Innovation, the Velux Foundation and the US National Institute of Health (P01 AG08761). The Minnesota Twin Study of Adult Development and Aging was supported by NIA grant R01 AG06886. VETSA was supported by National Institute of Health grants NIA R01 AG018384, R01 AG018386, R01 AG022381 and R01 AG022982, and, in part, with resources of the VA San Diego Center of Excellence for Stress and Mental Health. The Cooperative Studies Program of the Office of Research & Development of the United States Department of Veterans Affairs has provided financial support for the development and maintenance of the Vietnam Era Twin (VET) Registry. Data collection and analyses in the Finnish Twin Cohort and Finntwin16 have been supported by ENGAGE European Network for Genetic and Genomic Epidemiology, FP7-HEALTH-F4-2007, grant agreement number 201413, National Institute of Alcohol Abuse and Alcoholism (grants AA-12502, AA-00145 and AA-09203), the Academy of Finland Center of Excellence in Complex Disease Genetics (grant numbers: 213506, 129680) and the Academy of Finland (grants 100499, 205585, 118555, 141054, 265240, 263278, 264146, 308248 and 312073). This MIDUS study was supported by the John D. and Catherine T. MacArthur Foundation Research Network on Successful Midlife Development and by National Institute on Aging Grant AG20166. Funding for the Australian Over-50s twin study was supported by Mr. George Landers of Chania, Crete.We acknowledge the contribution of the OATS research team (https://cheba.unsw.edu.au/project/older-australiantwins- study) to this study. The OATS study has been funded by a National Health & Medical Research Council (NHMRC) and Australian Research Council (ARC) Strategic Award Grant of the Ageing Well, Ageing Productively Program (ID No. 401162) and NHMRC Project Grants (ID 1045325 and 1085606). OATS participant recruitment was facilitated through Twins Research Australia, a national resource in part supported by a Centre for Research Excellence Grant (ID: 1079102), from the National Health and Medical Research Council. We thank the participants for their time and generosity in contributing to this research. The Carolina African American Twin Study of Aging (CAATSA) was funded by NIA grant R01 AG13662. The Project Talent Twin Study has been supported by National Institute of Health grants R01 AG043656 and R01 AG056163, and development funds from American Institutes of Research. Funding for archiving the NAS-NRC Twin Registry data was provided by NIH Grant No. R21 AG039572. The content of this manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the NIA/NIH, or the VA.

Funding Information:
Financial support. IGEMS is supported by the National Institutes of Health Grants No. R01 AG037985, R56 AG037985, R01 AG059329, R01 AG060470, RF1 AG058068. SATSA was supported by grants R01 AG04563, R01 AG10175, the John D. and Catherine T. MacArthur Foundation Research Network on Successful Aging, the Swedish Council For Working Life and Social Research (FAS) (97:0147:1B, 2009-0795) and Swedish Research Council (825-2007-7460, 825-2009-6141). OCTO-Twin was supported by grant R01 AG08861. Gender was supported by the MacArthur Foundation Research Network on Successful Aging, The Axel and Margaret Ax:son Johnson’s Foundation, The Swedish Council for Social Research and the Swedish Foundation for Health Care Sciences and Allergy Research. TOSS was supported by grant R01 MH54610 from the National Institutes of Health. The Danish Twin Registry is supported by grants from The National Program for Research Infrastructure 2007 from the Danish Agency for Science and Innovation, the Velux Foundation and the US National Institute of Health (P01 AG08761). The Minnesota Twin Study of Adult Development and Aging was supported by NIA grant R01 AG06886. VETSA was supported by National Institute of Health grants NIA R01 AG018384, R01 AG018386, R01 AG022381 and R01 AG022982, and, in part, with resources of the VA San Diego Center of Excellence for Stress and Mental Health. The Cooperative Studies Program of the Office of Research & Development of the United States Department of Veterans Affairs has provided financial support for the development and maintenance of the Vietnam Era Twin (VET) Registry. Data collection and analyses in the Finnish Twin Cohort and Finntwin16 have been supported by ENGAGE — European Network for Genetic and Genomic Epidemiology, FP7-HEALTH-F4-2007, grant agreement number 201413, National Institute of Alcohol Abuse and Alcoholism (grants AA-12502, AA-00145 and AA-09203), the Academy of Finland Center of Excellence in Complex Disease Genetics (grant numbers: 213506, 129680) and the Academy of Finland (grants 100499, 205585, 118555, 141054, 265240, 263278, 264146, 308248 and 312073). This MIDUS study was supported by the John D. and Catherine T. MacArthur Foundation Research Network on Successful Midlife Development and by National Institute on Aging Grant AG20166. Funding for the Australian Over-50’s twin study was supported by Mr. George Landers of Chania, Crete. We acknowledge the contribution of the OATS research team (https://cheba.unsw.edu.au/project/older-australian-twins-study) to this study. The OATS study has been funded by a National Health & Medical Research Council (NHMRC) and Australian Research Council (ARC) Strategic Award Grant of the Ageing Well, Ageing Productively Program (ID No. 401162) and NHMRC Project Grants (ID 1045325 and 1085606). OATS participant recruitment was facilitated through Twins Research Australia, a national resource in part supported by a Centre for Research Excellence Grant (ID: 1079102), from the National Health and Medical Research Council. We thank the participants for their time and generosity in contributing to this research. The Carolina African American Twin Study of Aging (CAATSA) was funded by NIA grant R01 AG13662. The Project Talent Twin Study has been supported by National Institute of Health grants R01 AG043656 and R01 AG056163, and development funds from American Institutes of Research. Funding for archiving the NAS-NRC Twin Registry data was provided by NIH Grant No. R21 AG039572. The content of this manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the NIA/NIH, or the VA.

Publisher Copyright:
© The Author(s) 2019.

Keywords

  • Dementia
  • early life adversity
  • gene-environment interplay
  • health
  • socioeconomic status

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