Idiopathic hypercalciuria associated with hyperreninemia and high urinary prostaglandin E

M. Houser, B. Zimmerman, M. Davidman, C. Smith, A. Sinaiko, A. Fish

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25 Scopus citations


A patient with idiopathic hypercalciuria and some features suggestive of Bartter syndrome is reported. Excessive urinary prostaglandin E (PGE) excretion and renal calcium leak were documented in this child. Treatment with aspirin and indomethacin reduced urinary PGE excretion and was associated with a decrease in daily calcium excretion. At the lowest levels of urinary PGE, the renal calcium leak was no longer evident although mild hypercalciuria persisted. These results suggest that PGE may play a role in some cases of idiopathic hypercalciuria.

Original languageEnglish (US)
Pages (from-to)176-182
Number of pages7
JournalKidney international
Issue number2
StatePublished - 1984

Bibliographical note

Funding Information:
Acknowledgments This work was supported in part by United States Public Health Service grants Al 10704, HL 08570, and HL 17871, the Vikings Children's Fund, and grant RR 00400 from the General Research Cen-


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