Identity of the putative δ1-opioid receptor as a δ-κ heteromer in the mouse spinal cord

Philip S. Portoghese; Mary M. Lunzer

doi:10.1016/S0014-2999(03)01599-1

Identity of the putative δ₁-opioid receptor as a δ-κ heteromer in the mouse spinal cord

Philip S. Portoghese
, Mary M. Lunzer

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

In view of the co-localization of spinal δ- and κ-opioid receptors, we have investigated the interaction of selective opioid receptor agonists and antagonists in the spinal cord of mice in order to determine if these receptors are organized as heteromers. The finding that norbinaltorphimine (κ) antagonized [D-Pen^2,5]enkephalin (δ₁), but not deltorphin II (δ₂), strongly suggests that the putative δ₁-subtype is a δ-κ heteromer. Studies with selective opioid receptor (ant)agonists support this conclusion.

Original language	English (US)
Pages (from-to)	233-234
Number of pages	2
Journal	European Journal of Pharmacology
Volume	467
Issue number	1-3
DOIs	https://doi.org/10.1016/S0014-2999(03)01599-1
State	Published - Apr 25 2003

Bibliographical note

Funding Information:
This work was supported by the National Institute on Drug Abuse research grant R37 DA01533. The animal protocols used in these experiments were approved by the University of Minnesota Institutional Animal Care and Use Committee (IACUC).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Norbinaltorphimine
δ-Opioid receptor
δ-κ Heteromer

Publisher link

10.1016/S0014-2999(03)01599-1

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Cite this

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abstract = "In view of the co-localization of spinal δ- and κ-opioid receptors, we have investigated the interaction of selective opioid receptor agonists and antagonists in the spinal cord of mice in order to determine if these receptors are organized as heteromers. The finding that norbinaltorphimine (κ) antagonized [D-Pen2,5]enkephalin (δ1), but not deltorphin II (δ2), strongly suggests that the putative δ1-subtype is a δ-κ heteromer. Studies with selective opioid receptor (ant)agonists support this conclusion.",

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