Identity of the putative δ1-opioid receptor as a δ-κ heteromer in the mouse spinal cord

Philip S Portoghese, Mary M. Lunzer

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

In view of the co-localization of spinal δ- and κ-opioid receptors, we have investigated the interaction of selective opioid receptor agonists and antagonists in the spinal cord of mice in order to determine if these receptors are organized as heteromers. The finding that norbinaltorphimine (κ) antagonized [D-Pen2,5]enkephalin (δ1), but not deltorphin II (δ2), strongly suggests that the putative δ1-subtype is a δ-κ heteromer. Studies with selective opioid receptor (ant)agonists support this conclusion.

Original languageEnglish (US)
Pages (from-to)233-234
Number of pages2
JournalEuropean Journal of Pharmacology
Volume467
Issue number1-3
DOIs
StatePublished - Apr 25 2003

Fingerprint

Opioid Receptors
Spinal Cord
Ants
Narcotic Antagonists
Enkephalins
Ala(2)-deltorphin II
norbinaltorphimine

Keywords

  • Norbinaltorphimine
  • δ-Opioid receptor
  • δ-κ Heteromer

Cite this

Identity of the putative δ1-opioid receptor as a δ-κ heteromer in the mouse spinal cord. / Portoghese, Philip S; Lunzer, Mary M.

In: European Journal of Pharmacology, Vol. 467, No. 1-3, 25.04.2003, p. 233-234.

Research output: Contribution to journalArticle

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