Identification of NK cell receptor ligands using a signaling reporter system.

Yoshie Matsubayashi Iizuka, Nikunj V. Somia, Koho Iizuka

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

NK cell responses are regulated by a balance of inhibitory and activating signals, reflecting the net effect of interactions between receptors and ligands on target and effector cell surfaces. The identification of ligands for orphan NK cell receptors is key to enhancing our understanding of NK cell biology. Here we describe a strategy (protocol) for the identification of ligands for orphan NK cell receptors using signaling reporter cells in combination with a virus rescue system.

Original languageEnglish (US)
Pages (from-to)285-297
Number of pages13
JournalMethods in molecular biology (Clifton, N.J.)
Volume612
DOIs
StatePublished - 2010

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