Identification of methysticin as a potent and non-toxic NF-κB inhibitor from kava, potentially responsible for kava's chemopreventive activity

Ahmad Ali Shaik; David Lee Hermanson; Chengguo Xing

doi:10.1016/j.bmcl.2009.08.003

Identification of methysticin as a potent and non-toxic NF-κB inhibitor from kava, potentially responsible for kava's chemopreventive activity

Ahmad Ali Shaik, David Lee Hermanson, Chengguo Xing

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Nuclear factor-κB (NF-κB) is a transcription factor that plays an essential role in cancer development. The results of our recent chemopreventive study demonstrate that kava, a beverage in the South Pacific Islands, suppresses NF-κB activation in lung adenoma tissues, potentially a mechanism responsible for kava's chemopreventive activity. Methysticin is identified as a potent NF-κB inhibitor in kava with minimum toxicity. Other kava constituents, including four kavalactones of similar structures to methysticin, demonstrate minimum activities in inhibiting NF-κB.

Original language	English (US)
Pages (from-to)	5732-5736
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	19
DOIs	https://doi.org/10.1016/j.bmcl.2009.08.003
State	Published - Oct 1 2009

Bibliographical note

Funding Information:
This investigation was supported by Grant R03CA125844 from National Cancer Institute , NIH (C. Xing). We thank Thomas E. Johnson for synthesizing flavokawains A, B, and C for HPLC confirmation and Sonia Das for evaluating the cytotoxicity of methysticin in HL-60 and CCRF cell lines.

Keywords

Cancer
Kava
Methysticin
Nuclear factor-κB

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2009.08.003

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title = "Identification of methysticin as a potent and non-toxic NF-κB inhibitor from kava, potentially responsible for kava's chemopreventive activity",

abstract = "Nuclear factor-κB (NF-κB) is a transcription factor that plays an essential role in cancer development. The results of our recent chemopreventive study demonstrate that kava, a beverage in the South Pacific Islands, suppresses NF-κB activation in lung adenoma tissues, potentially a mechanism responsible for kava's chemopreventive activity. Methysticin is identified as a potent NF-κB inhibitor in kava with minimum toxicity. Other kava constituents, including four kavalactones of similar structures to methysticin, demonstrate minimum activities in inhibiting NF-κB.",

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AU - Shaik, Ahmad Ali

AU - Hermanson, David Lee

AU - Xing, Chengguo

N1 - Funding Information: This investigation was supported by Grant R03CA125844 from National Cancer Institute , NIH (C. Xing). We thank Thomas E. Johnson for synthesizing flavokawains A, B, and C for HPLC confirmation and Sonia Das for evaluating the cytotoxicity of methysticin in HL-60 and CCRF cell lines.

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N2 - Nuclear factor-κB (NF-κB) is a transcription factor that plays an essential role in cancer development. The results of our recent chemopreventive study demonstrate that kava, a beverage in the South Pacific Islands, suppresses NF-κB activation in lung adenoma tissues, potentially a mechanism responsible for kava's chemopreventive activity. Methysticin is identified as a potent NF-κB inhibitor in kava with minimum toxicity. Other kava constituents, including four kavalactones of similar structures to methysticin, demonstrate minimum activities in inhibiting NF-κB.

AB - Nuclear factor-κB (NF-κB) is a transcription factor that plays an essential role in cancer development. The results of our recent chemopreventive study demonstrate that kava, a beverage in the South Pacific Islands, suppresses NF-κB activation in lung adenoma tissues, potentially a mechanism responsible for kava's chemopreventive activity. Methysticin is identified as a potent NF-κB inhibitor in kava with minimum toxicity. Other kava constituents, including four kavalactones of similar structures to methysticin, demonstrate minimum activities in inhibiting NF-κB.

KW - Cancer

KW - Kava

KW - Methysticin

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Identification of methysticin as a potent and non-toxic NF-κB inhibitor from kava, potentially responsible for kava's chemopreventive activity

Abstract

Bibliographical note

Keywords

UN SDGs

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