Abstract
The flavoenzyme uridine 5′-diphosphate (UDP)-galactopyranose mutase (UGM) plays a key role in the cell wall biosynthesis of many pathogens, including Mycobacterium tuberculosis. Using a synthetic fluorescent ligand, we screened 16000 compounds in a fluorescence polarization assay. Effective inhibitors of UGM were identified.
Original language | English (US) |
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Pages (from-to) | 10532-10533 |
Number of pages | 2 |
Journal | Journal of the American Chemical Society |
Volume | 126 |
Issue number | 34 |
DOIs | |
State | Published - Sep 1 2004 |