Identification of inhibitors for UDP-galactopyranose mutase

Michelle Soltero-Higgin, Erin E. Carlson, John H. Phillips, Laura L. Kiessling

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

The flavoenzyme uridine 5′-diphosphate (UDP)-galactopyranose mutase (UGM) plays a key role in the cell wall biosynthesis of many pathogens, including Mycobacterium tuberculosis. Using a synthetic fluorescent ligand, we screened 16000 compounds in a fluorescence polarization assay. Effective inhibitors of UGM were identified.

Original languageEnglish (US)
Pages (from-to)10532-10533
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number34
DOIs
StatePublished - Sep 1 2004

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