Identification of genes differentially regulated by transcription factor, AP-2Delta

Liyun Sun, Shengdong Huang, Qihan Wu, Shaohua Gu, Xuping Fu, Ke Yu, Fanglin Lu, Chaoneng Ji, Congjing Feng, Ruping Sun, Yi Xie, Yumin Mao

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

In an effort to better understand the transcriptional program regulated by transcription factor, AP-2delta, we used cDNA microarray to evaluate the relative expression of human genes in AD293 cells by exogenous expression of AP-2delta. Microarry showed 29 genes that were up-regulated and 39 genes with a down-regulated expression pattern. Among the identified genes were those encoding transcription factors, signal transduction molecules, kinases, as well as genes regulating cell growth, differentiation, and cell adhesion, a set of genes suggested to be regulated by AP-2. The results of microarray was valided for some regulated genes by real-time PCR analysis.These observations shed novel insight into the mechanism of AP-2delta action and provide a range of target genes for further investigation.

Original languageEnglish (US)
Pages (from-to)1699-1706
Number of pages8
JournalFrontiers in Bioscience
Volume12
Issue number5
DOIs
StatePublished - 2007

Keywords

  • AP-2delta
  • INF-responsive
  • Microarray
  • TSSK
  • ZNF

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