Markedly dilated dystrophic post-ganglionic sympathetic axons have been identified by dopamine-β-hydroxylase immunohistochemistry in the paravascular ileal mesenteric nerves of rats with chronic streptozotocin diabetes. Many axons contained multiple dilatations with interposed axonal segments of near normal dimensions. These axonal abnormalities were absent in control animals. The time course of the development of the axonopathy and its distribution in the alimentary tract correlate with quantitative ultrastructural findings previously reported in this system.
Bibliographical noteFunding Information:
We would like to thank Dr. Boyd K. Hartman for providing the antibody to DBH. The assistance of Dr. Santiago B. Plurad in the ultrastructural investigations is gratefully acknowledged. Streptozotocin was kindly provided by the Up john Company. This study was supported by NIH Grant AM19645, Research Grant 81R-425 from the Juvenile Diabetes Foundation, and Biomedical Research Support Grant 3155-51420.
- autonomic (sympathetic) neuropathy
- axonal dystrophy
- experimental diabetes