Identification of dystrophic sympathetic axons in experimental diabetic autonomic neuropathy

H. Brent Clark, Robert E. Schmidt

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Markedly dilated dystrophic post-ganglionic sympathetic axons have been identified by dopamine-β-hydroxylase immunohistochemistry in the paravascular ileal mesenteric nerves of rats with chronic streptozotocin diabetes. Many axons contained multiple dilatations with interposed axonal segments of near normal dimensions. These axonal abnormalities were absent in control animals. The time course of the development of the axonopathy and its distribution in the alimentary tract correlate with quantitative ultrastructural findings previously reported in this system.

Original languageEnglish (US)
Pages (from-to)390-395
Number of pages6
JournalBrain Research
Volume293
Issue number2
DOIs
StatePublished - Feb 20 1984

Keywords

  • autonomic (sympathetic) neuropathy
  • axonal dystrophy
  • experimental diabetes

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