Abstract
We have identified chick frizzled (Fz)-10, encoding a Wnt receptor, and examined the expression pattern during embryogenesis. Fz-10 is expressed in the region posterior to the Hensen's node at stage 6. Fz-10 expression is detected in the dorsal domain of the neural tube and the central nervous system of the developing embryo. In the developing limb, Fz-10 expression starts at stage 18 in the posterior-dorsal region of the distal mesenchyme, and gradually expands to the anterior-distal region. Fz-10 is also expressed in the feather bud and branchial arch. Implantation of Sonic hedgehog (Shh)- expressing cells into the anterior margin of the limb bud resulted in the induction of Fz-10 expression in anterior-dorsal mesenchyme. (C) 2000 Elsevier Science Ireland Ltd.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 375-378 |
| Number of pages | 4 |
| Journal | Mechanisms of Development |
| Volume | 91 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Mar 1 2000 |
Bibliographical note
Funding Information:We are grateful to A. Shiga for technical assistance, Dr. S. Mackem for chick cDNA libraries, and J.K. Ng for reading manuscript. This work was supported in part by Grants-in-Aid from the Japanese Ministry of Education, Science, Sports and Culture to T.N., Y.K. and N.W., and by Research Project Grants from Kawasaki Medical School to T.N.
Keywords
- Epithelial- mesenchymal interaction
- Frizzled-10
- Limb development
- Sonic hedgehog
- Wnt
- Wnt receptor