Identification of autoxidation and photodegradation products of ethynylestradiol by on-line HPLC-NMR and HPLC-MS

Brigitte E. Segmuller; Barbara L. Armstrong; Richard Dunphy; Alan R. Oyler

doi:10.1016/S0731-7085(00)00363-0

Identification of autoxidation and photodegradation products of ethynylestradiol by on-line HPLC-NMR and HPLC-MS

Brigitte E. Segmuller, Barbara L. Armstrong, Richard Dunphy, Alan R. Oyler

Chemistry & Biochemistry

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

HPLC-NMR, HPLC-MS, and HPLC-UV were used to characterize the predominant solution autoxidation and photodegradation products of ethynylestradiol (1). A hydroperoxide (2) and a series of isomeric dimeric oxidation products (3-7), were identified. (C) 2000 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	927-937
Number of pages	11
Journal	Journal of Pharmaceutical and Biomedical Analysis
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/S0731-7085(00)00363-0
State	Published - Oct 2000

Keywords

Autoxidation
Estrogen
Ethynylestradiol
HPLC-MS
HPLC-NMR
Photodegradation

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10.1016/S0731-7085(00)00363-0

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abstract = "HPLC-NMR, HPLC-MS, and HPLC-UV were used to characterize the predominant solution autoxidation and photodegradation products of ethynylestradiol (1). A hydroperoxide (2) and a series of isomeric dimeric oxidation products (3-7), were identified. (C) 2000 Elsevier Science B.V.",

keywords = "Autoxidation, Estrogen, Ethynylestradiol, HPLC-MS, HPLC-NMR, Photodegradation",

author = "Segmuller, {Brigitte E.} and Armstrong, {Barbara L.} and Richard Dunphy and Oyler, {Alan R.}",

year = "2000",

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T1 - Identification of autoxidation and photodegradation products of ethynylestradiol by on-line HPLC-NMR and HPLC-MS

AU - Segmuller, Brigitte E.

AU - Armstrong, Barbara L.

AU - Dunphy, Richard

AU - Oyler, Alan R.

PY - 2000/10

Y1 - 2000/10

N2 - HPLC-NMR, HPLC-MS, and HPLC-UV were used to characterize the predominant solution autoxidation and photodegradation products of ethynylestradiol (1). A hydroperoxide (2) and a series of isomeric dimeric oxidation products (3-7), were identified. (C) 2000 Elsevier Science B.V.

AB - HPLC-NMR, HPLC-MS, and HPLC-UV were used to characterize the predominant solution autoxidation and photodegradation products of ethynylestradiol (1). A hydroperoxide (2) and a series of isomeric dimeric oxidation products (3-7), were identified. (C) 2000 Elsevier Science B.V.

KW - Autoxidation

KW - Estrogen

KW - Ethynylestradiol

KW - HPLC-MS

KW - HPLC-NMR

KW - Photodegradation

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VL - 23

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JO - Journal of Pharmaceutical and Biomedical Analysis

JF - Journal of Pharmaceutical and Biomedical Analysis

IS - 5

ER -

Identification of autoxidation and photodegradation products of ethynylestradiol by on-line HPLC-NMR and HPLC-MS

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