Identification of an essential glycoprotease in Staphylococcus aureus

Li Zheng, Junshu Yang, Christina Landwehr, Frank Fan, Yinduo Ji

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The emergence of multi-drug resistant bacterial pathogens is generating enormous public health concern, and highlights an urgent need for new, alternative agents for treating multi-drug-resistant pathogens. The gene products essential for bacterial growth in vitro and survival during infection constitute an initial set of protein targets for the development of antibacterial agents. In this study, we employed regulated gene expression approaches and demonstrated that a putative glycoprotease (Gcp) is required for staphylococcal growth in the culture. We found that Staphylococcus aureus becomes more sensitive to the Zn2+ ion under the downregulation of Gcp expression in vitro. Bioinformatic analyses demonstrated that Gcp is conserved in many Gram-positive pathogens and exists in a variety of Gram-negative pathogens. Our results indicate that Gcp is a potential novel target for the development of antimicrobials against S. aureus infection.

Original languageEnglish (US)
Pages (from-to)279-285
Number of pages7
JournalFEMS Microbiology Letters
Issue number2
StatePublished - Apr 15 2005


  • Antisense RNA
  • Glycoprotease (Gcp)
  • Staphylococcus aureus

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