Identification of adducts formed in the reactions of 5′-acetoxy- N′-nitrosonornicotine with deoxyadenosine, thymidine, and DNA

Keyphrases

• N'-nitrosonornicotine 100%
• Acetoxy 100%
• Deoxyadenosine 100%
• Thymidine 100%
• Pyridyl 80%
• NaBH3CN 80%
• Liquid Chromatography-electrospray Ionization-mass Spectrometry (LC-ESI-MS) 60%
• Electrospray Ionization Mass Spectrometry 60%
• Tobacco Products 40%
• Hydroxylation 40%
• Liver 20%
• Cytochrome P450 (CYP450) 20%
• DNA Adducts 20%
• Carcinogen 20%
• N-nitrosamines 20%
• Purine 20%
• Metabolic Pathway 20%
• Circulating Tumor DNA (ctDNA) 20%
• Tetrahydrofuran 20%
• Laboratory Animals 20%
• Deoxyribonucleosides 20%
• Deoxyribose 20%
• Spectral Properties 20%
• Adduct Formation 20%
• DNA Adduct Formation 20%
• N-nitrosopyrrolidine 20%
• Synthetic Standards 20%
• SRM Analysis 20%

Pharmacology, Toxicology and Pharmaceutical Science

• N-Nitrosonornicotine 100%
• Thymidine 100%
• Deoxyadenosine 100%
• Carcinogen 20%
• Experimental Animal 20%
• Tobacco-Specific Nitrosamines 20%
• Cytochrome P450 20%
• N Nitrosopyrrolidine 20%
• Deoxyribonucleoside 20%
• Tetrahydrofuran 20%
• Purine 20%