Identification of a molecular locus for normalizing dysregulated GABA release from interneurons in the Fragile X brain

Keyphrases

• Dysregulated 100%
• Interneuron 100%
• Basket Cell 100%
• GABA Release 100%
• Fragile X Mental Retardation 1 (FMR1) 80%
• Fragile X Mental Retardation Protein 80%
• Kv1.2 60%
• Synapse 40%
• Knock-in Mouse Model 40%
• Fragile X Syndrome 40%
• Purkinje Neuron 40%
• Ca2+ 20%
• Potassium Channel 20%
• Cerebellum 20%
• Autism 20%
• Dysregulation 20%
• Targeted Intervention 20%
• Fire Behavior 20%
• Neuropsychiatric Disorders 20%
• Inhibitory Control 20%
• Social Interaction 20%
• Excitability 20%
• C-terminus 20%
• Presynaptic Terminal 20%
• N-terminus 20%
• Docosahexaenoic Acid 20%
• Firing Rate 20%
• Membrane Depolarization 20%
• Patch-clamp Recording 20%
• Direct Injection 20%
• Acoustic Startle Reflex 20%
• Firing Pattern 20%
• Fire Frequency 20%
• Protein Antibody 20%
• GABAergic Interneurons 20%
• Phosphorylated Serine 20%
• N-terminal Fragment 20%
• Principal Neuron 20%
• Inhibitory Transmission 20%
• Cerebellar Circuitry 20%
• In-the-wild 20%

Neuroscience

• Basket Cell 100%
• Gamma-Aminobutyric Acid 100%
• Interneuron 100%
• Fragile X Mental Retardation Protein 80%
• Synapse 40%
• Fragile X Syndrome 40%
• Amino Terminal Sequence 40%
• In Vivo 20%
• C-Terminus 20%
• Patch Clamp Technique 20%
• Cerebellum 20%
• Social Interaction 20%
• Presynaptic Terminal 20%
• Autism 20%
• In Vitro 20%
• Serine 20%
• Agonist 20%
• Excitability 20%
• Firing Rate 20%
• Membrane Depolarization 20%
• Startle Response 20%
• Potassium Channel Kv1.2 20%
• Docosahexaenoic Acid 20%
• Protein Antibody 20%
• Psychopathology 20%