TY - JOUR
T1 - Identification of a dual specificity kinase that activates the jun kinases and p38-Mpk2
AU - Lin, Anning
AU - Minden, Audrey
AU - Martinetto, Horacio
AU - Claret, Francois Xavier
AU - Lange-Carter, Carol
AU - Mercurio, Frank
AU - Johnson, Gary L.
AU - Karin, Michael
PY - 1995
Y1 - 1995
N2 - One Ras-dependent protein kinase cascade leading from growth factor receptors to the ERK (extracellular signal-regulated kinases) subgroup of mitogen-activated protein kinases (MAPKs) is dependent on the protein kinase Raf-1, which activates the MEK (MAPK or ERK kinase) dual specificity kinases. A second protein kinase cascade leading to activation of the Jun kinases (JNKs) is dependent on MEKK (MEK kinase). A dual-specificity kinase that activates JNK, named JNKK, was identified that functions between MEKK and JNK. JNKK activated the JNKs but did not activate the ERKs and was unresponsive to Raf-1 in transfected HeLa cells. JNKK also activated another MAPK, p38 (Mpk2; the mammalian homolog of HOG1 from yeast), whose activity is regulated similarly to that of the JNKs.
AB - One Ras-dependent protein kinase cascade leading from growth factor receptors to the ERK (extracellular signal-regulated kinases) subgroup of mitogen-activated protein kinases (MAPKs) is dependent on the protein kinase Raf-1, which activates the MEK (MAPK or ERK kinase) dual specificity kinases. A second protein kinase cascade leading to activation of the Jun kinases (JNKs) is dependent on MEKK (MEK kinase). A dual-specificity kinase that activates JNK, named JNKK, was identified that functions between MEKK and JNK. JNKK activated the JNKs but did not activate the ERKs and was unresponsive to Raf-1 in transfected HeLa cells. JNKK also activated another MAPK, p38 (Mpk2; the mammalian homolog of HOG1 from yeast), whose activity is regulated similarly to that of the JNKs.
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U2 - 10.1126/science.7716521
DO - 10.1126/science.7716521
M3 - Article
C2 - 7716521
AN - SCOPUS:0028943245
VL - 268
SP - 286
EP - 290
JO - Science
JF - Science
SN - 0036-8075
IS - 5208
ER -