We report the discovery of a new splicing variant of vascular endothelial growth factor named VEGF183. It is six amino acids shorter than its closest relative, VEGF189, due to the utilization of a conserved alternate splicing donor site within exon 6a. Highly expressed in heart tissue, VEGF183 is detected in transiently transfected COS cells as 28-32- kDa monomers under reduced condition, and 46-kDa dimers under non-reduced condition - the functional unit for all VEGF isoforms.
|Original language||English (US)|
|Number of pages||7|
|Journal||Biochimica et Biophysica Acta - Gene Structure and Expression|
|State||Published - Dec 22 1998|
- Gene expression
- Splice variant
- Vascular endothelial growth factor