Abstract
We report the discovery of a new splicing variant of vascular endothelial growth factor named VEGF183. It is six amino acids shorter than its closest relative, VEGF189, due to the utilization of a conserved alternate splicing donor site within exon 6a. Highly expressed in heart tissue, VEGF183 is detected in transiently transfected COS cells as 28-32- kDa monomers under reduced condition, and 46-kDa dimers under non-reduced condition - the functional unit for all VEGF isoforms.
Original language | English (US) |
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Pages (from-to) | 400-406 |
Number of pages | 7 |
Journal | Biochimica et Biophysica Acta - Gene Structure and Expression |
Volume | 1443 |
Issue number | 3 |
DOIs | |
State | Published - Dec 22 1998 |
Bibliographical note
Funding Information:This work is supported in part by grants (to D.P.) from Arthritis Foundation (MN Chapter), American Cancer Society Institutional Grant, University of Minnesota Graduate School Grant-in-Aid program, Elsa Pardee Foundation, American Heart Association and National Cancer Institute.
Keywords
- Angiogenesis
- Gene expression
- Neovascularization
- Splice variant
- Vascular endothelial growth factor