Identification and characterization of a new splicing variant of vascular endothelial growth factor: VEGF183

Jianxun Lei, Aixiang Jiang, Duanqing Pei

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67 Scopus citations

Abstract

We report the discovery of a new splicing variant of vascular endothelial growth factor named VEGF183. It is six amino acids shorter than its closest relative, VEGF189, due to the utilization of a conserved alternate splicing donor site within exon 6a. Highly expressed in heart tissue, VEGF183 is detected in transiently transfected COS cells as 28-32- kDa monomers under reduced condition, and 46-kDa dimers under non-reduced condition - the functional unit for all VEGF isoforms.

Original languageEnglish (US)
Pages (from-to)400-406
Number of pages7
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Volume1443
Issue number3
DOIs
StatePublished - Dec 22 1998

Keywords

  • Angiogenesis
  • Gene expression
  • Neovascularization
  • Splice variant
  • Vascular endothelial growth factor

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