Id1 and NF-κB promote the generation of CD133+ and BMI-1+ keratinocytes and the growth of xenograft tumors in mice

Jinhuo Lai, Qian Cai, Merrill A. Biel, Chuan Wang, Xiaohua Hu, Shaoyuan Wang, Jizhen Lin

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Id1 and NF-κB are highly expressed in oral squamous cell carcinoma (OSCC). Whether they have a synergistic role in the carcinogenesis of OSCC is unclear. The current study was designed to demonstrate the synergy of both Id1 and NF-κ B in the underlying disease mechanisms of OSCC using in vitro and in vivo animal models. Id1 and NF-κ B strengthened the expression of both CD133 and BMI-1 in OSCC cell cultures. CD133+ and BMI-1+ keratinocytes from OSCC tissues and cell cultures initiated the growth of xenograft tumors in SCID/Beige mice. Id1 and NF-κB regulate the expression of CD133 and BMI-1 in an additive or synergistic manner in OSCC, which is associated with the generation of naïve and self-renewable keratinocytes and initiate the growth of xenograft tumors in vivo.

Original languageEnglish (US)
Pages (from-to)1481-1489
Number of pages9
JournalInternational Journal of Oncology
Volume44
Issue number5
DOIs
StatePublished - May 2014

Keywords

  • Cancer stem-like cells
  • Head and neck cancer
  • Id1
  • Nf-κb
  • OCT4
  • Oral squamous cell carcinoma

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