ICUD-EAU international consultation on bladder cancer 2012: Non-muscle-invasive urothelial carcinoma of the bladder

Maximilian Burger, Willem Oosterlinck, Badrinath Konety, Sam Chang, Sigurdur Gudjonsson, Raj Pruthi, Mark Soloway, Eduardo Solsona, Paul Sved, Marko Babjuk, Maurizio A. Brausi, Christopher Cheng, Eva Comperat, Colin Dinney, Wolfgang Otto, Jay Shah, Joachim Thürof, J. Alfred Witjes

Research output: Contribution to journalReview articlepeer-review

130 Scopus citations


Context: Our aim was to present a summary of the Second International Consultation on Bladder Cancer recommendations on the diagnosis and treatment options for non-muscle-invasive urothelial cancer of the bladder (NMIBC) using an evidence-based approach. Objective: To critically review the recent data on the management of NMIBC to arrive at a general consensus. Evidence acquisition: A detailed Medline analysis was performed for original articles addressing the treatment of NMIBC with regard to diagnosis, surgery, intravesical chemotherapy, and follow-up. Proceedings from the last 5 yr of major conferences were also searched. Evidence synthesis: The major findings are presented in an evidence-based fashion. We analyzed large retrospective and prospective studies. Conclusions: Urothelial cancer of the bladder staged Ta, T1, and carcinoma in situ (CIS), also indicated as NMIBC, poses greatly varying but uniformly demanding challenges to urologic care. On the one hand, the high recurrence rate and low progression rate with Ta low-grade demand risk-adapted treatment and surveillance to provide thorough care while minimizing treatment-related burden. On the other hand, the propensity of Ta high-grade, T1, and CIS to progress demands intense care and timely consideration of radical cystectomy.

Original languageEnglish (US)
Pages (from-to)36-44
Number of pages9
JournalEuropean Urology
Issue number1
StatePublished - Jan 2013

Bibliographical note

Copyright 2013 Elsevier B.V., All rights reserved.


  • Bacillus Calmette-Guérin (BCG)
  • Bladder cancer
  • Cystoscopy
  • Diagnosis
  • Guidelines
  • Intravesical chemotherapy
  • Prognosis
  • Transurethral resection (TUR)


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