ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: The multi-ethnic study of atherosclerosis (MESA)

Suzette J. Bielinski; James S. Pankow; Na Li; Fang Chi Hsu; Sara D. Adar; Nancy Swords Jenny; Donald W. Bowden; Bruce A. Wasserman; Donna Arnett

doi:10.1016/j.atherosclerosis.2008.02.031

ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: The multi-ethnic study of atherosclerosis (MESA)

Suzette J. Bielinski
, James S. Pankow
, Na Li
, Fang Chi Hsu
, Sara D. Adar
, Nancy Swords Jenny
, Donald W. Bowden
, Bruce A. Wasserman
, Donna Arnett

Epidemiology & Community Health

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) may be important contributors to the development and progression of atherosclerosis. Using a stratified random sample of 2880 participants of the Multi-Ethnic Study of Atherosclerosis we investigated the relationship of 12 ICAM1 and 17 VCAM1 SNPs and coronary artery calcium (CAC) and ICAM1 SNPs and circulating levels of soluble ICAM-1 (sICAM-1). There were no ICAM1 or VCAM1 SNPs significantly associated with CAC in any of the four race/ethnic groups. In a subset of 1451 subjects with sICAM-1 measurements, we observed a significant association with rs5491 in all four race/ethnic groups corroborating previous research that has shown that the T-allele of rs5491 interferes with the monoclonal antibody used to measure sICAM-1 in this study. After excluding all rs5491 T-allele carriers, several ICAM1 SNPs were significantly associated with sICAM-1 levels; rs5496 in African Americans, rs5498 and rs3093030 in European Americans, and rs1799969 in Hispanics. Our results identified ICAM1 polymorphisms that were significantly associated with sICAM-1 level but not CAC, a subclinical marker of atherosclerosis.

Original language	English (US)
Pages (from-to)	339-344
Number of pages	6
Journal	Atherosclerosis
Volume	201
Issue number	2
DOIs	https://doi.org/10.1016/j.atherosclerosis.2008.02.031
State	Published - Dec 2008

Bibliographical note

Funding Information:
The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. This research was supported by contracts N01-HC-95159 through N01-HC-95165, N01-HC-95169, R01-HL071250 through R01-HL071252, R01-HL071259, R01-HL071051, and R01-HL071205 from the National Heart, Lung, and Blood Institute. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org .

Keywords

Coronary artery calcium
Gene
Haplotypes
Intercellular adhesion molecule-1 (ICAM-1)
Single nucleotide polymorphism (SNP)
Soluble intercellular adhesion molecule-1 (sICAM-1)
Vascular adhesion molecule-1 (VCAM-1)

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10.1016/j.atherosclerosis.2008.02.031

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title = "ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: The multi-ethnic study of atherosclerosis (MESA)",

abstract = "Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) may be important contributors to the development and progression of atherosclerosis. Using a stratified random sample of 2880 participants of the Multi-Ethnic Study of Atherosclerosis we investigated the relationship of 12 ICAM1 and 17 VCAM1 SNPs and coronary artery calcium (CAC) and ICAM1 SNPs and circulating levels of soluble ICAM-1 (sICAM-1). There were no ICAM1 or VCAM1 SNPs significantly associated with CAC in any of the four race/ethnic groups. In a subset of 1451 subjects with sICAM-1 measurements, we observed a significant association with rs5491 in all four race/ethnic groups corroborating previous research that has shown that the T-allele of rs5491 interferes with the monoclonal antibody used to measure sICAM-1 in this study. After excluding all rs5491 T-allele carriers, several ICAM1 SNPs were significantly associated with sICAM-1 levels; rs5496 in African Americans, rs5498 and rs3093030 in European Americans, and rs1799969 in Hispanics. Our results identified ICAM1 polymorphisms that were significantly associated with sICAM-1 level but not CAC, a subclinical marker of atherosclerosis.",

keywords = "Coronary artery calcium, Gene, Haplotypes, Intercellular adhesion molecule-1 (ICAM-1), Single nucleotide polymorphism (SNP), Soluble intercellular adhesion molecule-1 (sICAM-1), Vascular adhesion molecule-1 (VCAM-1)",

author = "Bielinski, \{Suzette J.\} and Pankow, \{James S.\} and Na Li and Hsu, \{Fang Chi\} and Adar, \{Sara D.\} and Jenny, \{Nancy Swords\} and Bowden, \{Donald W.\} and Wasserman, \{Bruce A.\} and Donna Arnett",

note = "Funding Information: The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. This research was supported by contracts N01-HC-95159 through N01-HC-95165, N01-HC-95169, R01-HL071250 through R01-HL071252, R01-HL071259, R01-HL071051, and R01-HL071205 from the National Heart, Lung, and Blood Institute. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org . ",

year = "2008",

month = dec,

doi = "10.1016/j.atherosclerosis.2008.02.031",

language = "English (US)",

volume = "201",

pages = "339--344",

journal = "Atherosclerosis",

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T1 - ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1

T2 - The multi-ethnic study of atherosclerosis (MESA)

AU - Bielinski, Suzette J.

AU - Pankow, James S.

AU - Li, Na

AU - Hsu, Fang Chi

AU - Adar, Sara D.

AU - Jenny, Nancy Swords

AU - Bowden, Donald W.

AU - Wasserman, Bruce A.

AU - Arnett, Donna

N1 - Funding Information: The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. This research was supported by contracts N01-HC-95159 through N01-HC-95165, N01-HC-95169, R01-HL071250 through R01-HL071252, R01-HL071259, R01-HL071051, and R01-HL071205 from the National Heart, Lung, and Blood Institute. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org .

PY - 2008/12

Y1 - 2008/12

N2 - Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) may be important contributors to the development and progression of atherosclerosis. Using a stratified random sample of 2880 participants of the Multi-Ethnic Study of Atherosclerosis we investigated the relationship of 12 ICAM1 and 17 VCAM1 SNPs and coronary artery calcium (CAC) and ICAM1 SNPs and circulating levels of soluble ICAM-1 (sICAM-1). There were no ICAM1 or VCAM1 SNPs significantly associated with CAC in any of the four race/ethnic groups. In a subset of 1451 subjects with sICAM-1 measurements, we observed a significant association with rs5491 in all four race/ethnic groups corroborating previous research that has shown that the T-allele of rs5491 interferes with the monoclonal antibody used to measure sICAM-1 in this study. After excluding all rs5491 T-allele carriers, several ICAM1 SNPs were significantly associated with sICAM-1 levels; rs5496 in African Americans, rs5498 and rs3093030 in European Americans, and rs1799969 in Hispanics. Our results identified ICAM1 polymorphisms that were significantly associated with sICAM-1 level but not CAC, a subclinical marker of atherosclerosis.

AB - Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) may be important contributors to the development and progression of atherosclerosis. Using a stratified random sample of 2880 participants of the Multi-Ethnic Study of Atherosclerosis we investigated the relationship of 12 ICAM1 and 17 VCAM1 SNPs and coronary artery calcium (CAC) and ICAM1 SNPs and circulating levels of soluble ICAM-1 (sICAM-1). There were no ICAM1 or VCAM1 SNPs significantly associated with CAC in any of the four race/ethnic groups. In a subset of 1451 subjects with sICAM-1 measurements, we observed a significant association with rs5491 in all four race/ethnic groups corroborating previous research that has shown that the T-allele of rs5491 interferes with the monoclonal antibody used to measure sICAM-1 in this study. After excluding all rs5491 T-allele carriers, several ICAM1 SNPs were significantly associated with sICAM-1 levels; rs5496 in African Americans, rs5498 and rs3093030 in European Americans, and rs1799969 in Hispanics. Our results identified ICAM1 polymorphisms that were significantly associated with sICAM-1 level but not CAC, a subclinical marker of atherosclerosis.

KW - Coronary artery calcium

KW - Gene

KW - Haplotypes

KW - Intercellular adhesion molecule-1 (ICAM-1)

KW - Single nucleotide polymorphism (SNP)

KW - Soluble intercellular adhesion molecule-1 (sICAM-1)

KW - Vascular adhesion molecule-1 (VCAM-1)

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UR - https://www.scopus.com/pages/publications/56649089864#tab=citedBy

U2 - 10.1016/j.atherosclerosis.2008.02.031

DO - 10.1016/j.atherosclerosis.2008.02.031

M3 - Article

C2 - 18420209

AN - SCOPUS:56649089864

SN - 0021-9150

VL - 201

SP - 339

EP - 344

JO - Atherosclerosis

JF - Atherosclerosis

IS - 2

ER -

ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: The multi-ethnic study of atherosclerosis (MESA)

Abstract

Bibliographical note

Keywords

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