ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: The multi-ethnic study of atherosclerosis (MESA)

Suzette J. Bielinski, James S. Pankow, Na Li, Fang Chi Hsu, Sara D. Adar, Nancy Swords Jenny, Donald W. Bowden, Bruce A. Wasserman, Donna Arnett

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) may be important contributors to the development and progression of atherosclerosis. Using a stratified random sample of 2880 participants of the Multi-Ethnic Study of Atherosclerosis we investigated the relationship of 12 ICAM1 and 17 VCAM1 SNPs and coronary artery calcium (CAC) and ICAM1 SNPs and circulating levels of soluble ICAM-1 (sICAM-1). There were no ICAM1 or VCAM1 SNPs significantly associated with CAC in any of the four race/ethnic groups. In a subset of 1451 subjects with sICAM-1 measurements, we observed a significant association with rs5491 in all four race/ethnic groups corroborating previous research that has shown that the T-allele of rs5491 interferes with the monoclonal antibody used to measure sICAM-1 in this study. After excluding all rs5491 T-allele carriers, several ICAM1 SNPs were significantly associated with sICAM-1 levels; rs5496 in African Americans, rs5498 and rs3093030 in European Americans, and rs1799969 in Hispanics. Our results identified ICAM1 polymorphisms that were significantly associated with sICAM-1 level but not CAC, a subclinical marker of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)339-344
Number of pages6
JournalAtherosclerosis
Volume201
Issue number2
DOIs
StatePublished - Dec 1 2008

Keywords

  • Coronary artery calcium
  • Gene
  • Haplotypes
  • Intercellular adhesion molecule-1 (ICAM-1)
  • Single nucleotide polymorphism (SNP)
  • Soluble intercellular adhesion molecule-1 (sICAM-1)
  • Vascular adhesion molecule-1 (VCAM-1)

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