TY - JOUR
T1 - Iatrogenic excessive blood pressure variability (CHAT)
T2 - Implications for chronotherapy
AU - Cornelissen-Guillaume, Germaine G
AU - Halberg, F.
AU - Otsuka, K.
AU - Shinagawa, M.
AU - Kubo, Y.
AU - Ohkawa, S.
AU - Fišer, B.
AU - Siegelová, J.
AU - Dušek, J.
PY - 2003/12/1
Y1 - 2003/12/1
N2 - The aim of the study was to describe circadian hyper-amplitude-tension (CHAT) in an 82-year-old man treated with sotalol hydrochloride (Betapace), a beta-adrenoceptor blocker with class III anti-arrhythmic properties. Our results showed an increase in diastolic blood pressure, assessed as rhythm-adjusted mean value (MESOR), after treatment withdrawal and a decrease in both systolic and diastolic blood pressure (MESOR) after resuming treatment. This was accompanied by a considerable decrease in the double amplitude of both systolic and diastolic blood pressure.
AB - The aim of the study was to describe circadian hyper-amplitude-tension (CHAT) in an 82-year-old man treated with sotalol hydrochloride (Betapace), a beta-adrenoceptor blocker with class III anti-arrhythmic properties. Our results showed an increase in diastolic blood pressure, assessed as rhythm-adjusted mean value (MESOR), after treatment withdrawal and a decrease in both systolic and diastolic blood pressure (MESOR) after resuming treatment. This was accompanied by a considerable decrease in the double amplitude of both systolic and diastolic blood pressure.
KW - Chronotherapy
KW - Circadian variability
KW - Essential hypertension
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M3 - Article
AN - SCOPUS:2642533017
SN - 1211-3395
VL - 76
SP - 275
EP - 278
JO - Scripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae
JF - Scripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae
IS - 5
ER -