Iatrogenic excessive blood pressure variability (CHAT): Implications for chronotherapy

Germaine G Cornelissen-Guillaume, F. Halberg, K. Otsuka, M. Shinagawa, Y. Kubo, S. Ohkawa, B. Fišer, J. Siegelová, J. Dušek

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The aim of the study was to describe circadian hyper-amplitude-tension (CHAT) in an 82-year-old man treated with sotalol hydrochloride (Betapace), a beta-adrenoceptor blocker with class III anti-arrhythmic properties. Our results showed an increase in diastolic blood pressure, assessed as rhythm-adjusted mean value (MESOR), after treatment withdrawal and a decrease in both systolic and diastolic blood pressure (MESOR) after resuming treatment. This was accompanied by a considerable decrease in the double amplitude of both systolic and diastolic blood pressure.

Original languageEnglish (US)
Pages (from-to)275-278
Number of pages4
JournalScripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae
Issue number5
StatePublished - Dec 1 2003


  • Chronotherapy
  • Circadian variability
  • Essential hypertension


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