Iatrogenic excessive blood pressure variability (CHAT): Implications for chronotherapy

Germaine G Cornelissen-Guillaume, F. Halberg, K. Otsuka, M. Shinagawa, Y. Kubo, S. Ohkawa, B. Fišer, J. Siegelová, J. Dušek

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Abstract

The aim of the study was to describe circadian hyper-amplitude-tension (CHAT) in an 82-year-old man treated with sotalol hydrochloride (Betapace), a beta-adrenoceptor blocker with class III anti-arrhythmic properties. Our results showed an increase in diastolic blood pressure, assessed as rhythm-adjusted mean value (MESOR), after treatment withdrawal and a decrease in both systolic and diastolic blood pressure (MESOR) after resuming treatment. This was accompanied by a considerable decrease in the double amplitude of both systolic and diastolic blood pressure.

Original languageEnglish (US)
Pages (from-to)275-278
Number of pages4
JournalScripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae
Volume76
Issue number5
StatePublished - Dec 1 2003

Keywords

  • Chronotherapy
  • Circadian variability
  • Essential hypertension

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    Cornelissen-Guillaume, G. G., Halberg, F., Otsuka, K., Shinagawa, M., Kubo, Y., Ohkawa, S., Fišer, B., Siegelová, J., & Dušek, J. (2003). Iatrogenic excessive blood pressure variability (CHAT): Implications for chronotherapy. Scripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae, 76(5), 275-278.