Hysteroscopy and cytology in endometrial cancer

William H. Bradley, Matthew P. Boente, Doris Brooker, Peter A Argenta, Levi S Downs, Patricia L. Judson, Linda F Carson

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

To estimate the effect of preoperative diagnostic hysteroscopy on peritoneal cytology in patients with endometrial cancer. A total of 256 charts were reviewed. Two cohorts were established based on diagnosis by hysteroscopy or blind endometrial sampling via either endometrial biopsy or dilatation and curettage (D&C). Malignant or suspicious peritoneal cytology was the primary outcome. Cohorts were compared using logistic regression to correct for potential confounders of stage and grade. A total of 204 cases were diagnosed by endometrial biopsy or D&C, whereas 52 were identified by hysteroscopy. In the endometrial biopsy or D&C arm, 14 of 204 (6.9%) patients had malignant or suspicious cytology compared with 7 of 52 (13.5%) patients in the hysteroscopy arm (P = .15). After logistic regression controlling for stage and grade, the odds ratio for positive cytology after hysteroscopy was 3.88 (95% confidence interval 1.11,13.6; P = .03). Four of the 52 (7.7%) cases diagnosed by hysteroscopy were stage IIIA due to cytology alone compared with 3 of the 204 (1.4%) cases diagnosed by endometrial biopsy or D&C (P = .03). Hysteroscopy appears to be associated with an increased rate of malignant cytology after controlling for confounders of stage and grade. Further, there appears to be an association between hysteroscopy and upstaging patients due to cytology alone. II-2.

Original languageEnglish (US)
Pages (from-to)1030-1033
Number of pages4
JournalObstetrics and Gynecology
Volume104
Issue number5
DOIs
StatePublished - Jan 1 2004

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Hysteroscopy
Endometrial Neoplasms
Cell Biology
Biopsy
Dilatation and Curettage
Logistic Models
Odds Ratio
Confidence Intervals

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Bradley, W. H., Boente, M. P., Brooker, D., Argenta, P. A., Downs, L. S., Judson, P. L., & Carson, L. F. (2004). Hysteroscopy and cytology in endometrial cancer. Obstetrics and Gynecology, 104(5), 1030-1033. https://doi.org/10.1097/01.AOG.0000143263.19732.18

Hysteroscopy and cytology in endometrial cancer. / Bradley, William H.; Boente, Matthew P.; Brooker, Doris; Argenta, Peter A; Downs, Levi S; Judson, Patricia L.; Carson, Linda F.

In: Obstetrics and Gynecology, Vol. 104, No. 5, 01.01.2004, p. 1030-1033.

Research output: Contribution to journalArticle

Bradley, WH, Boente, MP, Brooker, D, Argenta, PA, Downs, LS, Judson, PL & Carson, LF 2004, 'Hysteroscopy and cytology in endometrial cancer', Obstetrics and Gynecology, vol. 104, no. 5, pp. 1030-1033. https://doi.org/10.1097/01.AOG.0000143263.19732.18
Bradley WH, Boente MP, Brooker D, Argenta PA, Downs LS, Judson PL et al. Hysteroscopy and cytology in endometrial cancer. Obstetrics and Gynecology. 2004 Jan 1;104(5):1030-1033. https://doi.org/10.1097/01.AOG.0000143263.19732.18
Bradley, William H. ; Boente, Matthew P. ; Brooker, Doris ; Argenta, Peter A ; Downs, Levi S ; Judson, Patricia L. ; Carson, Linda F. / Hysteroscopy and cytology in endometrial cancer. In: Obstetrics and Gynecology. 2004 ; Vol. 104, No. 5. pp. 1030-1033.
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