Abstract
Inhibition of the synthesis of endothelium derived relaxing factor by NG-monomethyl-L-arginine, a competitive inhibitor of the synthesis of nitric oxide from L-arginine, enhances hypoxic pulmonary vasoconstriction in pulmonary artery rings and isolated, Krebs albumin perfused rat lungs. L-arginine rapidly reduces hypoxic vasoconstriction, particularly in lungs treated with NG-monomethyl-L-arginine. Following administration of NG-monomethyl-L-arginine, bradykinin-induced vasodilation is inhibited (p<0.01) and a bradykinin-induced vasoconstriction develops (p<0.001). NG-monomethyl-L-arginine does not significantly diminish acetylcholine-induced vasodilatation in the isolated lung. NG-monomethyl-L-arginine causes an endothelium-dependent vasoconstriction in pulmonary artery rings.
Original language | English (US) |
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Pages (from-to) | 1198-1205 |
Number of pages | 8 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 164 |
Issue number | 3 |
DOIs | |
State | Published - Nov 15 1989 |
Bibliographical note
Funding Information:This work was supported by the Veterans Administration.