Hypothyroxinemia in critically ill patients as a predictor of high mortality

M. F. Slag, J. E. Morley, M. K. Elson, T. W. Crowson, F. Q. Nuttall, R. B. Shafer

Research output: Contribution to journalArticlepeer-review

197 Scopus citations


Thyroid function was measured in 86 patients hospitalized in an intensive care unit. Two patients were found to have primary hypothyroidism and were excluded from the study. Hypothyroxinemia with normal thyroid-stimulating hormone (TSH) levels was found in 22% of the patients and was associated with a high mortality (thyroxine [T 4] levels less than 3.0 μg/dL, 84% mortality; T 4 levels of 3.0 to 5.0 μg/dL, 50% mortality; and T 4 levels greater than 5.0 μg/dL, 15% mortality). There was a high correlation between low T 4 levels and mortality.

Original languageEnglish (US)
Pages (from-to)43-45
Number of pages3
JournalJournal of the American Medical Association
Issue number1
StatePublished - 1981


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