Hypothyroidism after cancer and the ability to meet reproductive goals among a cohort of young adult female cancer survivors

Helen B. Chin, Melanie H. Jacobson, Julia D. Interrante, Ann C. Mertens, Jessica B. Spencer, Penelope P. Howards

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective To determine whether developing hypothyroidism after cancer treatment is associated with a decreased probability of women being able to meet their reproductive goals. Design A population-based cohort study. Setting Not applicable. Patient(s) A total of 1,282 cancer survivors, of whom 904 met the inclusion criteria for the analysis. Intervention(s) None. Main Outcome Measure(s) Three outcomes that may indicate reduced fertility, which include failure to achieve desired family size, childlessness, and not achieving pregnancy after at least 6 months of regular unprotected intercourse. Result(s) We used data from the Furthering Understanding of Cancer Health and Survivorship in Adult (FUCHSIA) Women's Study to examine the association between being diagnosed with hypothyroidism after cancer and meeting reproductive goals. After adjusting for age and other potential confounders, women reporting hypothyroidism after cancer treatment were twice as likely to fail to achieve their desired family size (adjusted odds ratio [aOR] 1.91; 95% confidence interval [CI], 1.09, 3.33) and be childless (aOR 2.13; 95% CI, 1.25, 3.65). They were also more likely to report having unprotected intercourse for at least 6 months without conceiving (aOR 1.37; 95% CI, 0.66, 2.83). Conclusion(s) Although cancer treatments themselves are gonadotoxic, it is important to consider other medical conditions such as hypothyroidism that occur after cancer treatment when counseling patients on the risks for impaired fertility or a shortened reproductive window.

Original languageEnglish (US)
Pages (from-to)202-207.e2
JournalFertility and Sterility
Volume105
Issue number1
DOIs
StatePublished - 2016
Externally publishedYes

Bibliographical note

Funding Information:
Supported by the National Institutes of Health , Eunice Kennedy Shriver National Institute of Child Health and Human Development (grant 1R01HD066059 ); Reproductive, Perinatal, & Pediatric Training (grant T32HD052460 ); and the Health Resources and Service Administration Training (grant T03MC07651–06 ).

Publisher Copyright:
© 2016 American Society for Reproductive Medicine.

Keywords

  • Cancer survivors
  • hypothyroidism
  • infertility

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