The paraventricular hypothalamic nucleus (PVN) appears to integrate orexigenic properties of a novel peptide, ghrelin. Thus, we examined central mechanisms underlying feeding generated by intra-PVN ghrelin. We established that 0.03nmol of PVN-injected ghrelin was the lowest dose increasing food consumption and it induced c-Fos immunoreactivity (a marker of neuronal activation) in the PVN itself, as well as in other feeding-related brain areas, including the hypothalamic arcuate and dorsomedial nuclei, central nucleus of the amygdala, and nucleus of the solitary tract. We conclude that the PVN, as part of larger central circuitry, mediates orexigenic properties of ghrelin.
Bibliographical noteFunding Information:
This project was supported by NIH, National Research Service Award T32DA07097 from the National Institute of Drug Abuse, by the Department of Veterans Affairs, by the National Institute of Drug abuse Grant DA-03999, and by the National Institutes of Diabetes and Digestive and Kidney Disease Grant DK-42698 and P30 DK-50456.
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- Brain stem
- Food intake