Hyponatremia from oxcarbazepine and carbamazepine

Xiaoming Dong, Ilo E. Leppik, James White, John Rarick

Research output: Contribution to journalArticlepeer-review

146 Scopus citations


The authors examined sodium concentrations from 97 oxcarbazepine-treated (OXC) and 451 carbamazepine-treated (CBZ) patients with epilepsy using cross-section and follow-up studies. The frequency of hyponatremia (Na + ≤134 mEq/L) was 29.9% among OXC-treated patients and 13.5% among CBZ-treated patients (p < 0.0001). Hyponatremia (Na+ ≤128 mEq/L) was severe: 12.4% of OXC-treated patients and 2.8% of CBZ-treated patients (p < 0.001). Advanced age was a risk factor for hyponatremia. Hyponatremia, once present, persisted in both groups.

Original languageEnglish (US)
Pages (from-to)1976-1978
Number of pages3
Issue number12
StatePublished - Dec 2005


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