Hyponatremia as a Predictor of Cryptococcal Meningitis and Death among Asymptomatic Persons with HIV and Cryptococcal Antigenemia

Alice Lehman; Elizabeth Nalintya; Abduljewad Wele; Paul Kirumira; Rose Naluyima; Teopista Namuli; Fred Turya Musa; Caleb P. Skipper; David B. Meya; David R. Boulware; Radha Rajasingham

doi:10.1093/ofid/ofad156

Hyponatremia as a Predictor of Cryptococcal Meningitis and Death among Asymptomatic Persons with HIV and Cryptococcal Antigenemia

Alice Lehman, Elizabeth Nalintya, Abduljewad Wele, Paul Kirumira, Rose Naluyima, Teopista Namuli, Fred Turya Musa, Caleb P. Skipper, David B. Meya, David R. Boulware, Radha Rajasingham

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Among persons with human immunodeficiency virus–associated cryptococcal meningitis serum hyponatremia is a risk factor for mortality; however, the role of hyponatremia in persons with asymptomatic cryptococcal antigenemia is unknown. We found that serum hyponatremia ≤130 mmol/L is an independent risk factor for progression to meningitis and death in asymptomatic persons with cryptococcal antigenemia.

Original language	English (US)
Article number	ofad156
Journal	Open Forum Infectious Diseases
Volume	10
Issue number	3
DOIs	https://doi.org/10.1093/ofid/ofad156
State	Published - Mar 1 2023

Bibliographical note

Funding Information:
This work was supported by the National Institute of Allergy and Infectious Diseases (award numbers U01AI125003, K23AI138851, and T32AI055433) and the National Center for Advancing Translational Sciences (award numbers KL2TR002492 and UL1TR002494).

Publisher Copyright:
© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Keywords

HIV
cryptococcal meningitis
hyponatremia

PubMed: MeSH publication types

Journal Article

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ofid/ofad156

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Lehman, A., Nalintya, E., Wele, A., Kirumira, P., Naluyima, R., Namuli, T., Musa, F. T., Skipper, C. P., Meya, D. B., Boulware, D. R., & Rajasingham, R. (2023). Hyponatremia as a Predictor of Cryptococcal Meningitis and Death among Asymptomatic Persons with HIV and Cryptococcal Antigenemia. Open Forum Infectious Diseases, 10(3), Article ofad156. https://doi.org/10.1093/ofid/ofad156

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title = "Hyponatremia as a Predictor of Cryptococcal Meningitis and Death among Asymptomatic Persons with HIV and Cryptococcal Antigenemia",

abstract = "Among persons with human immunodeficiency virus–associated cryptococcal meningitis serum hyponatremia is a risk factor for mortality; however, the role of hyponatremia in persons with asymptomatic cryptococcal antigenemia is unknown. We found that serum hyponatremia ≤130 mmol/L is an independent risk factor for progression to meningitis and death in asymptomatic persons with cryptococcal antigenemia.",

keywords = "HIV, cryptococcal meningitis, hyponatremia",

author = "Alice Lehman and Elizabeth Nalintya and Abduljewad Wele and Paul Kirumira and Rose Naluyima and Teopista Namuli and Musa, {Fred Turya} and Skipper, {Caleb P.} and Meya, {David B.} and Boulware, {David R.} and Radha Rajasingham",

note = "Funding Information: This work was supported by the National Institute of Allergy and Infectious Diseases (award numbers U01AI125003, K23AI138851, and T32AI055433) and the National Center for Advancing Translational Sciences (award numbers KL2TR002492 and UL1TR002494). Publisher Copyright: {\textcopyright} The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

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AU - Lehman, Alice

AU - Nalintya, Elizabeth

AU - Wele, Abduljewad

AU - Kirumira, Paul

AU - Naluyima, Rose

AU - Namuli, Teopista

AU - Musa, Fred Turya

AU - Skipper, Caleb P.

AU - Meya, David B.

AU - Boulware, David R.

AU - Rajasingham, Radha

N1 - Funding Information: This work was supported by the National Institute of Allergy and Infectious Diseases (award numbers U01AI125003, K23AI138851, and T32AI055433) and the National Center for Advancing Translational Sciences (award numbers KL2TR002492 and UL1TR002494). Publisher Copyright: © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

PY - 2023/3/1

Y1 - 2023/3/1

N2 - Among persons with human immunodeficiency virus–associated cryptococcal meningitis serum hyponatremia is a risk factor for mortality; however, the role of hyponatremia in persons with asymptomatic cryptococcal antigenemia is unknown. We found that serum hyponatremia ≤130 mmol/L is an independent risk factor for progression to meningitis and death in asymptomatic persons with cryptococcal antigenemia.

AB - Among persons with human immunodeficiency virus–associated cryptococcal meningitis serum hyponatremia is a risk factor for mortality; however, the role of hyponatremia in persons with asymptomatic cryptococcal antigenemia is unknown. We found that serum hyponatremia ≤130 mmol/L is an independent risk factor for progression to meningitis and death in asymptomatic persons with cryptococcal antigenemia.

KW - HIV

KW - cryptococcal meningitis

KW - hyponatremia

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ER -

Hyponatremia as a Predictor of Cryptococcal Meningitis and Death among Asymptomatic Persons with HIV and Cryptococcal Antigenemia

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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