Hypomagnesemia linked to new-onset diabetes mellitus after kidney transplantation: A systematic review and meta-analysis

Wisit Cheungpasitporn, Charat Thongprayoon, Tasma Harindhanavudhi, Peter J. Edmonds, Stephen B. Erickson

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Abstract: Background: New-onset diabetes after kidney transplantation (NODAT) is associated with both renal allograft failure and increased mortality. The objective of this meta-analysis was to evaluate the risk of NODAT in patients with hypomagnesemia. Methods: A literature search was performed using MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews from inception through May, 2015. Studies that reported relative risks, odd ratios or hazard ratios comparing the risk of NODAT in patients with hypomagnesemia were included. Pooled risk ratios (RR) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method. Results: Five cohort studies with 1699 patients were included in the analysis to assess the risk of NODAT in patients with hypomagnesemia. The pooled RR of NODAT in patients with hypomagnesemia was 1.25 (95% CI, 1.08–1.45). When meta-analysis was limited only to studies with the post-transplant hypomagnesemia, the pooled RR of NODAT was 1.22 (95% CI, 1.09–1.38). Conclusion: Our meta-analysis demonstrates a significant association between hypomagnesemia and NODAT in kidney transplant recipients. This finding suggests the need for a large randomized controlled trial–with very careful attention to assess the effects of normalizing Mg levels and the risk of NODAT.

Original languageEnglish (US)
Pages (from-to)142-147
Number of pages6
JournalEndocrine Research
Volume41
Issue number2
DOIs
StatePublished - Apr 2 2016

Keywords

  • Electrolytes
  • graft
  • hypomagnesaemia
  • hypomagnesemia
  • kidney
  • magnesium
  • meta-analysis
  • new-onset diabetes
  • transplantation

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