Hypocretin I in the lateral hypothalamus activates key feeding- regulatory brain sites

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Abstract

Hypocretin I (also referred to as orexin A) administered into the lateral hypothalamus (LH) stimulates feeding in rats. We undertook the present study to determine the brain regions activated by LH administration of hypocretin I. Hypocretin I administered into the LH significantly elevated cFos-immunoreactivity in the lateral septal area, the central nucleus of the amygdala, the shell of the nucleus accumbens, the bed nucleus of the stria terminalis, the LH, the posterior and dorsomedial hypothalamus, the perifonical, arcuate and paraventricular nuclei and the nucleus of the solitary tract. These data indicate that LH hypocretin I communicates with other key energy regulatory sites within the hypothalamus, the limbic region and the hindbrain, and suggest that these areas are important in the feeding- stimulatory actions of hypocretin I.

Original languageEnglish (US)
Pages (from-to)103-108
Number of pages6
JournalNeuroreport
Volume11
Issue number1
DOIs
StatePublished - Jan 17 2000

Keywords

  • Brain Pathways
  • Hypocretin
  • Lateral hypothalamus
  • Orexin
  • cFos immunohistochemistry, Feeding behavior

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