TY - JOUR
T1 - Hyperviscosity as a possible cause of positive acoustic evoked potential findings in patients with sleep apnea
T2 - A dual electrophysiological and hemorheological study
AU - Bernáth, István
AU - McNamara, Patrick
AU - Szternák, Nóra
AU - Szakács, Zoltán
AU - Köves, Péter
AU - Terray-Horváth, Attila
AU - Vida, Zsuzsanna
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2009/3
Y1 - 2009/3
N2 - Objective: To test the hypothesis that blood hyperviscosity could account for the controversial results observed during electrophysiological evaluation of the brain stem in sleep apnea syndrome. Methods: This was a prospective study of a sample of patients with sleep apnea who were participating in a stroke prevention evaluation. Participants were 610 male patients with obstructive sleep apnea, aged 30-55 years, without large vessel disease on Magnetic Resonance Angiography and neck Doppler sonography, and an infratentorial lesion on head magnetic resonance imaging. Brainstem auditory-evoked potential and hemorheological investigations were carried out. Results: Forty-six percent (N = 282) of the patients evidenced hyperviscosity and 53% (N = 328) had normal rheological findings. Evoked potential changes appeared only in the hyperviscosity positive subgroup. Of these, 84% (N = 239) evidenced BAEP changes with 24% (N = 57) demonstrating sensorineuronal and 76% (N = 182) demonstrating brain stem type abnormalities. After six months of CPAP therapy, hyperviscosity was normalized in 66% (N = 159) of patients. BAEP wave III latency values were normalized in 70% (N = 112) of these patients. Conclusions: Viscosity changes play an important role in the brainstem electrophysiological abnormalities in apnea patients. These abnormalities can be normalized after six months of CPAP therapy.
AB - Objective: To test the hypothesis that blood hyperviscosity could account for the controversial results observed during electrophysiological evaluation of the brain stem in sleep apnea syndrome. Methods: This was a prospective study of a sample of patients with sleep apnea who were participating in a stroke prevention evaluation. Participants were 610 male patients with obstructive sleep apnea, aged 30-55 years, without large vessel disease on Magnetic Resonance Angiography and neck Doppler sonography, and an infratentorial lesion on head magnetic resonance imaging. Brainstem auditory-evoked potential and hemorheological investigations were carried out. Results: Forty-six percent (N = 282) of the patients evidenced hyperviscosity and 53% (N = 328) had normal rheological findings. Evoked potential changes appeared only in the hyperviscosity positive subgroup. Of these, 84% (N = 239) evidenced BAEP changes with 24% (N = 57) demonstrating sensorineuronal and 76% (N = 182) demonstrating brain stem type abnormalities. After six months of CPAP therapy, hyperviscosity was normalized in 66% (N = 159) of patients. BAEP wave III latency values were normalized in 70% (N = 112) of these patients. Conclusions: Viscosity changes play an important role in the brainstem electrophysiological abnormalities in apnea patients. These abnormalities can be normalized after six months of CPAP therapy.
KW - Blood hyperviscosity
KW - Brain stem auditory evoked potential
KW - Obstructive sleep apnea
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U2 - 10.1016/j.sleep.2008.03.012
DO - 10.1016/j.sleep.2008.03.012
M3 - Article
C2 - 18656422
AN - SCOPUS:64449084459
SN - 1389-9457
VL - 10
SP - 361
EP - 367
JO - Sleep Medicine
JF - Sleep Medicine
IS - 3
ER -