In this chapter, we outline the use of hypertonic saline in children (18years old or younger) with traumatic brain injury. We begin with an overview of the use of hyperosmolar therapy in traumatic brain injury followed by the history and evolution of hypertonic saline in the clinical setting. We then briefly review the pathophysiology of traumatic brain injury and the proposed mechanisms by which hypertonic saline affects the injury in children. We then discuss the more clinical aspects of hypertonic saline—this includes the various available concentrations of hypertonic saline as well as the practicalities of using hypertonic saline, such as the indications of use, recommended monitoring, and potential adverse effects. Finally, we end with highlighting the evidence behind the use of hypertonic saline in children.
|Original language||English (US)|
|Title of host publication||Diagnosis and Treatment of Traumatic Brain Injury|
|Subtitle of host publication||The Neuroscience of Traumatic Brain Injury|
|Number of pages||16|
|State||Published - Jan 1 2022|
Bibliographical notePublisher Copyright:
© 2022 Elsevier Inc. All rights reserved.
- Cerebral edema
- Hyperosmolar therapy
- Hypertonic saline
- Traumatic brain injury