Hypertonic saline usage in traumatic brain injury: A focus on pediatrics

Andrew Wu, Tina Slusher, Andrew Kiragu

Research output: Chapter in Book/Report/Conference proceedingChapter


In this chapter, we outline the use of hypertonic saline in children (18years old or younger) with traumatic brain injury. We begin with an overview of the use of hyperosmolar therapy in traumatic brain injury followed by the history and evolution of hypertonic saline in the clinical setting. We then briefly review the pathophysiology of traumatic brain injury and the proposed mechanisms by which hypertonic saline affects the injury in children. We then discuss the more clinical aspects of hypertonic saline—this includes the various available concentrations of hypertonic saline as well as the practicalities of using hypertonic saline, such as the indications of use, recommended monitoring, and potential adverse effects. Finally, we end with highlighting the evidence behind the use of hypertonic saline in children.

Original languageEnglish (US)
Title of host publicationDiagnosis and Treatment of Traumatic Brain Injury
Subtitle of host publicationThe Neuroscience of Traumatic Brain Injury
PublisherElsevier Inc.
Number of pages16
ISBN (Electronic)9780128233474
ISBN (Print)9780128233481
StatePublished - Jan 1 2022

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Inc. All rights reserved.


  • Cerebral edema
  • Hyperosmolar therapy
  • Hypertonic saline
  • Pediatrics
  • Traumatic brain injury


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