Hypertensive pulmonary vascular disease

A histologic study was made of the pulmonary vascular bed among subjects with the complete type of persistent common atrioventricular canal. Comparison was made between those with and those without associated Down syndrome (mongolism). No major difference was observed. These observations, therefore, cannot support the impression that in this anomaly, hypertensive pulmonary vascular disease is more severe and occurs earlier in those with Down syndrome than in those without.