Hypertension, Hyperlipidemia, and Renal Damage

William F. Keane, Bertram L. Kasiske, Michael P. O'Donnell, Youngki Kim

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Experimental studies have demonstrated that a number of factors participate in the progression of renal disease. Systemic and glomerular hypertension have been shown to be critical factors in renal injury. Hyperlipidemia that frequently coexists with renal disease also has been suggested as an important participatory factor in nephron damage. Interestingly, both hypertension and hyperlipidemia seem to evoke glomerular growth, a factor that has also been postulated to be involved in glomerular and tubular destruction. Recently, experimental and clinical data suggest that an important interaction occurs between hyperlipidemia and hypertension. Not only do they frequently coexist, but hypertension dramatically exaggerates hyperlipidemic injury, and hyperlipidemia alters systemic and glomerular vascular production of vasoactive substances which maintain basal vascular tone. Thus, these recent observations underscore the interactive potential of the various risk factors that participate in progression of renal disease. They also suggest that multiple interventional strategies may be needed to optimally prevent progressive nephron loss.

Original languageEnglish (US)
Pages (from-to)43-50
Number of pages8
JournalAmerican Journal of Kidney Diseases
Volume21
Issue number5
DOIs
StatePublished - 1993

Bibliographical note

Funding Information:
From the Division of Nephrology, Department of Medicine, Hennepin County Medical Center, Minneapolis, MN; and the Department of Pediatrics, University Hospital, University of Minnesota Medical School, Minneapolis, MN. This work was supported in part from grants received from the Baxter Extramural Grant Program and the American Heart Association. Address reprint requests to William F. Keane, MD, Division of Nephrology, Department of Medicine, Hennepin County Medical Center, 701 Park Ave S, Minneapolis, MN 55415. © 1993 by the National Kidney Foundation, Inc. 0272-6386/93/2105-2008$3.00/0

Keywords

  • Hypertension
  • antilipemic agents
  • glomerulosclerosis
  • hyperlipidemia
  • modified low-density lipoproteins
  • progression

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