Hyperpyrexia Associated With Intravenous Cimetidine Therapy: Report of a Case

• Fever as a drug reaction is common. It has, however, not been widely recognized as a complication of cimetidine therapy. We observed a patient who, during the administration of intravenous cimetidine, became hyperpyretic and confused. Six hours after cimetidine therapy was discontinued, he became afebrile. The potential for hyperpyrexia to occur with cimetidine should be considered in patients with unexplained fever who are receiving this drug.