Prostaglandin E2 was infused into the thoracic aorta of thyroparathyroidectomized (TPTX) and intact rats. Circulating calcium increased significantly in the TPTX group by 30 minutes and reached an increment of 1.5 ± 0.21 mg/dl (x ± SE, p<.001) by 90 minutes. No calcium increments were observed in the intact rats. It is postulated that prior failures to demonstrate hypercalcemia during PGE2 infusion may have been due to calcitonin counterregulation.
Bibliographical noteFunding Information:
This work was supported in part by Veterans Administration Research and Education Program (MRIS No. 7511) and NIH Grant HD-0482. Dr. Baylink (MRIS No. 0483) is a recipient of RCDA DE 19108. Reprint requests to R. Paul Robertson, M. D., Veterans Administration Hospital, 4435 Beacon Avenue South, Seattle, Washington 98108.