Hydrotropic solutions

Travis K. Hodgdon, Eric W. Kaler

Research output: Contribution to journalReview articlepeer-review

182 Scopus citations


Hydrotropes are a class of amphiphilic molecules that cannot form well organized structures, such as micelles, in water but do increase the aqueous solubility of organic molecules. Often strong synergistic effects are observed when hydrotropes are added to aqueous surfactant or polymer solutions. Recent studies regarding the effects of hydrotropes on phase behavior, aggregation, surface tension, viscosity, solubility, and microstructure formation are reviewed. Novel applications of hydrotropes as molecular probes and for controlled release of pharmaceuticals are also discussed.

Original languageEnglish (US)
Pages (from-to)121-128
Number of pages8
JournalCurrent Opinion in Colloid and Interface Science
Issue number3
StatePublished - Jun 2007


  • Branched micelle
  • Cloud point
  • Controlled release
  • Hydrotrope
  • Micelle transition
  • Molecular probe
  • Phase behavior
  • Sodium salicylate
  • Sodium tosylate
  • Surfactant polymerization


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