Hydrophobically assembled nanoparticles: Self-assembled nanoparticles

Jonathan Wang, Michael Mellas, Matthew Tirrell, Eun Ji Chung

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Hydrophobically self-assembled nanoparticles offer unique control over molecular behavior for biomedical engineering applications. Nanoparticle size, charge, and surface modifications heavily influence outcomes in a high-performance material for drug delivery or clinical imaging applications. Four main classes of molecules have seen significant progress in biomedical engineering applications in the past two decades: (1) peptide amphiphiles, (2) nucleic acid constructs, (3) block copolymers, and (4) dendrimers. We will focus on an introduction to the principles behind their hydrophobic self-assembly and highlight key studies demonstrating the advantages conferred by their supramolecular architecture.

Original languageEnglish (US)
Title of host publicationNanoparticles for Biomedical Applications
Subtitle of host publicationFundamental Concepts, Biological Interactions and Clinical Applications
Number of pages23
ISBN (Electronic)9780128166628
ISBN (Print)9780128166635
StatePublished - Jan 1 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc. All rights reserved.


  • Drug delivery
  • Hydrophilic
  • Hydrophobic
  • Imaging
  • Nanoparticle
  • Self-assembly


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