Hydrophilic annulated dinuclear zinc(II) phthalocyanine as Type II photosensitizers for PDT:

Angelo D. Quartarolo, Dimitri Pérusse, Fabienne Dumoulin, Nino Russo, Emilia Sicilia

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The design, synthesis and theoretical calculations of a mononuclear and its corresponding annulated dinuclear hydrophilic zinc(II) phthalocyanines (ZnPcs) are reported here, the hydrophilic substituent being 1,3-bis((2,2-dimethyl-1,3- dioxolan-4-yl)methoxy)propan-2-ol. These novel compounds have been characterized by UV-vis spectroscopy in ethanol and ethanol:water (50:50) solutions. The electronic spectra of the mononuclear derivatives retain the main spectral features of ZnPc with a strong Q-band absorbance at 678 nm in ethanol and a less intense B-band at 370 nm. The annulated dinuclear derivatives show a broad Q-band absorbance with main wavelength maxima between 600 and 720 nm. From time-dependent density functional (TDDFT) UV-vis spectra simulation performed on selected isomers, Q-band absorption maxima of the non-peripherally substituted forms are more red-shifted compared to those of peripheral forms.

Original languageEnglish (US)
Pages (from-to)980-988
Number of pages9
JournalJournal of Porphyrins and Phthalocyanines
Volume17
Issue number10
DOIs
StatePublished - Oct 2013

Bibliographical note

Funding Information:
Financial support from the Università degli Studi della Calabria is gratefully acknowledged. NR thanks UAM for Càtedra Dr. Raùl Remigio Cetina Rosado.

Keywords

  • annulated zinc phthalocyanine
  • photodynamic therapy
  • time-dependent density functional

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