Hydrodynamics of DNA confined in nanoslits and nanochannels

K. D. Dorfman, D. Gupta, A. Jain, A. Muralidhar, D. R. Tree

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


Modeling the dynamics of a confined, semiflexible polymer is a challenging problem, owing to the complicated interplay between the configurations of the chain, which are strongly affected by the length scale for the confinement relative to the persistence length of the chain, and the polymer-wall hydrodynamic interactions. At the same time, understanding these dynamics are crucial to the advancement of emerging genomic technologies that use confinement to stretch out DNA and “read” a genomic signature. In this mini-review, we begin by considering what is known experimentally and theoretically about the friction of a wormlike chain such as DNA confined in a slit or a channel. We then discuss how to estimate the friction coefficient of such a chain, either with dynamic simulations or via Monte Carlo sampling and the Kirkwood pre-averaging approximation. We then review our recent work on computing the diffusivity of DNA in nanoslits and nanochannels, and conclude with some promising avenues for future work and caveats about our approach.

Original languageEnglish (US)
Pages (from-to)3179-3200
Number of pages22
JournalEuropean Physical Journal: Special Topics
Issue number14
StatePublished - Dec 16 2014

Bibliographical note

Publisher Copyright:
© 2014, EDP Sciences and Springer.


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