Hydrating for resistance to radicicol

Adam S. Duerfeldt, Brian S.J. Blagg

Research output: Contribution to journalShort surveypeer-review

2 Scopus citations


Resistance to Hsp90 inhibition has become an important concern as several clinical trials are currently in progress for the treatment of cancer. A summary of known mechanisms of resistance to Hsp90 inhibitors is provided, including the recent solution of the Humicola fuscoatra Hsp90 structure, the organism responsible for the biosynthesis of radicicol. Through careful analyses of Hsp90 structures, a plausible mechanism for resistance to Hsp90 inhibitors has been obtained by single mutations about the N-terminal ATP-binding site.

Original languageEnglish (US)
Pages (from-to)245-247
Number of pages3
JournalACS Chemical Biology
Issue number4
StatePublished - Apr 17 2009
Externally publishedYes


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