Injection through a circular port oriented normally to a Mach 1.6 crossflow is simulated using hybrid Reynoldsaveraged Navier-Stokes and large-eddy simulation turbulence models. The simulations compare the performance of two related turbulence models. The standard formulation of the detached-eddy simulation equations is used in the context of a wall-modeled large-eddy simulation. A recently developed derivative of the detached-eddy simulation formulation that was aimed at improving performance when operating as a wall-modeled large-eddy simulation is also used. These methods are used such that the large-scale turbulent structure of the flowfield can be resolved while simulating realistic Reynolds numbers. Simulations are performed on two grids to assess the influence of grid resolution. Comparisons with flowfield visualizations from experiments are used to determine if the proper largescale structure is being resolved.Athorough validation of the results is performed by comparing with measurements of mean wall pressure from pressure-sensitive paint and measurements of mean velocity and turbulence intensities from laser Doppler velocimetry. Results from the simulations are found to be in good agreement with the experiment.